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Details for Product No. ABIN302064

V-Myc Myelocytomatosis Viral Oncogene Homolog (Avian) (MYC) antibody (HRP)

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Antigen
Synonyms MRTL, MYCC, bHLHe39, c-Myc, CMYC, c-myc, RNCMYC, mMyc, C-MYC, MYC, cmyc, zc-myc, AU016757, Myc2, Niard, Nird, LOC100136746
Reactivity
»Alternatives Human, All Species
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
Application
»Alternatives Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN302064
Quantity 0.1 mg
Price
515.46 $   Plus shipping costs $45.00
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Availability Will be delivered in 4 to 5 Business Days
Immunogen Synthetic peptide sequence (AEEQKLISEEDLL) corresponding to the C-terminal region ofhuman c-Myc.
Clone 9E10
Isotype IgG1
Specificity The antibody 9E10 may be used to detect the c-Myc tag.The c-myc gene (8q24 on human chromosome) is the cellular homologue of the v-mycgene originally isolated from an avian myelocytomatosis virus. The c-Myc protein is atranscription factor (nuclear localization). c-Myc is commonly activated in a variety of tumorcells and plays an important role in cellular proliferation, differentiation, apoptosis and cellcycle progression. The phosphorylation of c-Myc has been investigated and previousstudies have suggested a functional association between phosphorylation at Thr58/Ser62 byglycogen synthase kinase 3, cyclin-dependent kinase, ERK2 and C-Jun N-terminal Kinase(JNK) in cell proliferation and cell cycle regulation. In normal cells the expression of c-Myc istightly regulated but in human cancers c-Myc is frequently deregulated. c-Myc is alsoessential for tumor cell development in vasculogenesis and angiogenesis that distributeblood throughout the cells.
Alternative Name MYC
Research Area Cancer, Cell Cycle, Transcription Factors
Application Notes The reagent is designed for analysis. Suggested working dilution is 1: 500.Indicated dilution is recommended starting point for use of this product. Working concentrations should be determined by the investigator.
Restrictions For Research Use only
Concentration 1 mg/ml
Buffer The reagent is provided in phosphate buffered saline (PBS) containing 0.01% (w/v)thimerosal and 1% (w/v) high-grade protease free Bovine Serum Albumin (BSA) as astabilizing agent.
Preservative Thimerosal (Merthiolate)
Storage 4 °C
Hilpert, Hansen, Wessner et al.: "Anti-c-myc antibody 9E10: epitope key positions and variability characterized using peptide spot synthesis on cellulose." in: Protein engineering, Vol. 14, Issue 10, pp. 803-6, 2001 (PubMed).

Baggio, Burgstaller, Hale et al.: "Identification of epitope-like consensus motifs using mRNA display." in: Journal of molecular recognition : JMR, Vol. 15, Issue 3, pp. 126-34, 2002 (PubMed).

Fujiwara, Poikonen, Aleman et al.: "A single-chain antibody/epitope system for functional analysis of protein-protein interactions." in: Biochemistry, Vol. 41, Issue 42, pp. 12729-38, 2002 (PubMed).

Wang, Campoli, Ko et al.: "Enhancement of scFv fragment reactivity with target antigens in binding assays following mixing with anti-tag monoclonal antibodies." in: Journal of immunological methods, Vol. 294, Issue 1-2, pp. 23-35, 2004 (PubMed).

Veracini, Simon, Richard et al.: "The Csk-binding protein PAG regulates PDGF-induced Src mitogenic signaling via GM1." in: The Journal of cell biology, Vol. 182, Issue 3, pp. 603-14, 2008 (PubMed).

Alternatives for antigen "V-Myc Myelocytomatosis Viral Oncogene Homolog (Avian) (MYC)", type "Antibodies"
Hosts (295), (155), (19), (17), (4), (4)
Reactivities (436), (196), (168), (28), (26), (25), (25), (20), (13), (7), (6), (5), (5), (5), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Applications (345), (155), (127), (123), (117), (85), (50), (50), (42), (21), (10), (8), (7), (7), (6), (1), (1)
Conjugates (28), (24), (18), (7), (5), (5), (5), (5), (5), (5), (5), (5), (2), (1), (1), (1), (1), (1)
Epitopes (43), (41), (33), (32), (25), (18), (11), (10), (9), (6), (5), (5), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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