IER3 antibody (Center)

Catalog No. ABIN302818

This Rabbit Polyclonal antibody specifically detects IER3 in WB and IHC (p). It exhibits reactivity toward Human and Mouse.

Quick Overview for IER3 antibody (Center) (ABIN302818)

Target: IER3 (Immediate Early Response 3 (IER3))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IER3 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-IER3 Antibody

Binding Specificity: Center

Specificity: A 24 amino acid peptide near the center of Human IEX1.

Cross-Reactivity (Details): Species reactivity (expected):Mouse.
Species reactivity (tested):Human.

Purification: Immunoaffinity Chromatography

Immunogen: Synthetic peptide - KLH conjugated corresponding to a 24 amino acid peptide near the center of Human IEX1

Isotype: IgG

Application Details

Application Notes: Western Blot: 2-4 μg/mL. Immunohistochemistry on Paraffin Sections: 5 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: DO NOT FREEZE!!

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8 °C.

Target Details for IER3

Target: IER3 (Immediate Early Response 3 (IER3))

Alternative Name: IER3 / IEX1

Background: IEX-1 was originally characterized as a gene induced by ultraviolet radiation and TNF-alpha, which protected human squamous carcinoma cells from apoptosis. Subsequent transfection studies have also shown that expression of IEX-1 in human keratinocytes and mouse fibroblasts results in more rapid proliferation of the cells as compared with controls. The IEX-1 promoter contains binding motifs for both NFKB and p53, suggesting that these proteins may regulate its expression. IEX-1 expression may be modulated by AML1 and TPO.Synonyms: DIF2, Differentiation-dependent gene 2 protein, GLY96, IEX-1, Immediate early protein GLY96, Immediate early response 3 protein, PACAP-responsive gene 1 protein, PRG1, Radiation-inducible immediate-early gene IEX-1

Gene ID: 8870

NCBI Accession: NP_003888

UniProt: P46695

Pathways: Regulation of Carbohydrate Metabolic Process