X-Box Binding Protein 1 (XBP1) antibody

Antigen: X-Box Binding Protein 1 (XBP1)

Synonyms: XBP2, TREB5, XBP-1, TREB-5, D11Ertd39e, cb918, treb5, trebf, xbp1a, xbp1b, id:ibd1195, wu:fb02h05, wu:fb63f10, HTF, xbp1, MGC53678, MGC130816, xbp2, xXBP1, MGC76163, XBP1, XBPP1, MGC127699

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)

Catalog no.: ABIN302900

Additional Information

Characteristics: Synonyms: XBP-1, XBP2, X-box-binding protein 1, Tax-responsive element-binding protein 5

Alternative name: XBP1 / TREB5

Swiss-Prot: P17861

Immunogen: Synthetic peptide corresponding to a 17 amino acid peptide from near the Carboxyterminus of XBP-1.

Cross-Reactivity: Human, Mouse (Murine), Rat (Rattus)

Description: This gene encodes a transcription factor that regulates MHC class II genes by binding to apromoter element referred to as an X box. The protein contains two domains commonlyfound in transcription factors that confer DNA binding and dimerization capability. Thisgene product was also separately identified as a cellular transcription factor that binds toan enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increaseexpression of viral proteins by acting as the DNA binding partner of a viral transactivator. There is also a recent finding that the same agents that cause an ER stress response, theunfolded protein response, also increase transcription of this gene. This increase intranscription requires an ER stress response consensus binding element in the promoter.

Specificity: This antibody reacts to a 17 amino acid peptide from near the carboxy terminus of XBP-1. Species: Human, Mouse and Rat. Others not tested.

Application Details

Application Notes: Immunohistochemistry on Paraffin Sections: 5 µg/ml. Western Blot: 1-2 µg/ml. Immunocytochemistry. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.

Concentration: 1.0 mg/ml

Purification: Aff - Purified

Buffer: Phosphate buffered saline, containing 0.02% Sodium Azide aspreservative.

Storage: Store the antibody undiluted at 2-8°C for one month or in (aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Restrictions: For Research Use only