Adiponectin Receptor 1 (ADIPOR1) antibody

Antigen: Adiponectin Receptor 1 (ADIPOR1)

Synonyms: ADIPOR1, adipor1, zgc:92893, CGI45, PAQR1, ACDCR1, CGI-45, TESBP1A, FLJ25385, FLJ42464, Paqr1, 2810031L11Rik, zgc:55386, wu:fj02d08, MGC127115, cgi45, paqr1, acdcr1, cgi-45, tesbp1a, MGC79827, MGC53458, MGC114758, Adipor1

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Western Blotting (WB)

Catalog no.: ABIN306945

Additional Information

Alternative name: Adiponectin Receptor 1

Swiss-Prot: Q96A54

Isotype: Not determined  (Matching secondary antibodies)

Description: Alzheimer's disease (AD) is characterized by formation of plaques of amyloid beta peptide (Abeta). Autosomally-inherited AD had been shown only in connection with coding sequence mutations. Likely transcription factors whose mutation can cause loss of function are ADR1, MIG1, and PuF, and for gain of function, E12/E47, ITF-2, and RFX2. Adr1 controls the expression of genes required for ethanol, glycerol, and fatty acid utilization (in yeast). Adr1 can act directly on the promoters of ADH2, ACS1, GUT1, CTA1, and POT1. The yeast homolog of the AMP-activated protein kinase, Snf1, promotes Adr1 chromatin binding in the absence of glucose, and the protein phosphatase complex, Glc7.Reg1, represses its binding in the presence of glucose. A post-translational process is invloved in the regulation of Adr1 binding. Chromatin binding by Adr1 is not the only step in ADH2 transcription that is regulated by glucose repression, Adr1 can bind to chromatin in repressed conditions in the presence of hyperacetylated histones. In yeast, nuclear extracts prepared from glucose-repressed and glucose-derepressed cells are equally capable of supporting miniAdr1-dependent transcription and pre-initiation complex formation. Synonyms: Adiponectin receptor protein 1, Progestin and adipoQ receptor family member I, ADIPOR1, PAQR1,CGI-45.

Synonyms: ADIPOR1, adipor1, zgc:92893, CGI45, PAQR1, ACDCR1, CGI-45, TESBP1A, FLJ25385, FLJ42464, Paqr1, 2810031L11Rik, zgc:55386, wu:fj02d08, MGC127115, cgi45, paqr1, acdcr1, cgi-45, tesbp1a, MGC79827, MGC53458, MGC114758, Adipor1

Application Details

Application Notes: Antibody can be used for Western blotting (5-10ug/ml) and ELISA. Positive Control: Highly expressed in skeletal muscle. Expressed at intermediate level in brain, heart, spleen, kidney, liver, placenta, lung and peripheral blood leukocytes. .

Concentration: 1 mg/ml

Storage: Product should be stored at -20C. Aliquot to avoid freeze/thaw cycles

Research Area: Receptors

Restrictions: For Research Use only