5-Aminoimidazole-4-Carboxamide Ribonucleotide Formyltransferase/IMP Cyclohydrolase (ATIC) antibody

Antigen: 5-Aminoimidazole-4-Carboxamide Ribonucleotide Formyltransferase/IMP Cyclohydrolase (ATIC)

Clonality: Monoclonal (F38 P7 H9)

Host: Mouse

Reactivity: Human, Frog, Fruit Fly (Drosophila melanogaster), Rat (Rattus), Mouse (Murine)

Application: Western Blotting (WB)

Catalog no.: ABIN307123

Additional Information

Alternative name: ATIC

Swiss-Prot: P31939

Isotype: IgG1  (Matching secondary antibodies)

Clone: F38 P7 H9

Description: The bifunctional purine biosynthesis protein PURH contains phosphoribosylaminoimidazole carboxamide formyltransferase, also designated AICAR transformylase, IMP cyclohydrolase or Inosinicase. AICAR plays an important role in purine biosynthesis, specifically in the production of nucleotides and IMP. Defects in ATIC, the gene encoding for this protein, can cause AICArebosuria, also designated AICA-ribosiduria, an inborn error in purine biosynthesis that is neurologically cataclysmic. Individuals with AICA-rebosuria accumulate AICA-ribotide, also designated ZMP, and its derivatives in erythrocytes and fibroblasts and also excrete very large amounts of AICA-riboside in the urine. Mental retardation, epilepsy, dysmorphic features and congenital blindness are all symptoms of this disease. Synonyms: AICAR, AICARFT, AICARFT/IMPCHASE, PURH, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase.

Application Details

Application Notes: Antibody can be used for Western blotting (1-2 ug/ml) and immunohistochemistry on formalin-fixed, paraffin-embedded tissues (1-5 ug/ml). Positive Control: Colorectal cancer tissue..

Storage: Product should be stored at -20C. Aliquot to avoid freeze/thaw cycles

Restrictions: For Research Use only