PPAP2A antibody (N-Term)

Catalog No. ABIN310386

Product Details anti-PPAP2A Antibody

Target: PPAP2A (Phosphatidic Acid Phosphatase Type 2A (PPAP2A))

Binding Specificity: N-Term

Reactivity: Human, Rat, Mouse, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PPAP2A antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: QIYPFQRGFF CKDNSINYPY HDSTVTSTVL ILVGVGLPIS SIILGETLSV

Predicted Reactivity: Guinea Pig: 86%, Human: 100%, Mouse: 79%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against PPAP2A. It was validated on Western Blot and immunohistochemistry.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human PPAP2A

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 285 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-PPAP2A antibody (ABIN310386)

Evseenko, Latour, Richardson, Corselli, Sahaghian, Cardinal, Zhu, Chan, Dunn, Crooks: "Lysophosphatidic acid mediates myeloid differentiation within the human bone marrow microenvironment." in: PLoS ONE, Vol. 8, Issue 5, pp. e63718, (2013) (PubMed).

Target Details for PPAP2A

Target: PPAP2A (Phosphatidic Acid Phosphatase Type 2A (PPAP2A))

Alternative Name: PPAP2A (PPAP2A Products)

Background: PPAP2A is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is an integral membrane glycoprotein, and has been shown to be a surface enzyme that plays an active role in the hydrolysis and uptake of lipids from extracellular space.The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is an integral membrane glycoprotein, and has been shown to be a surface enzyme that plays an active role in the hydrolysis and uptake of lipids from extracellular space. The expression of this gene is found to be regulated by androgen in a prostatic adenocarcinoma cell line. At least two alternatively spliced transcript variants encoding distinct isoforms have been described.
Alias Symbols: LLP1a, LPP1, PAP-2a, PAP2, PAP2a2, PAP2alpha2, PAPalpha1
Protein Interaction Partner: FAHD1, IGF2BP2, ILF3, UBC, FXYD1,
Protein Size: 285

Molecular Weight: 31 kDa

Gene ID: 8611

NCBI Accession: NM_176895, NP_795714

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway