ATP1B1 antibody (Middle Region)

Catalog No. ABIN310596

This anti-ATP1B1 antibody is a Rabbit Polyclonal antibody detecting ATP1B1 in WB and IHC. Suitable for Human, Mouse, Rat, Rabbit, Dog, Cow, Guinea Pig, Sheep, Horse and Pig.

Quick Overview for ATP1B1 antibody (Middle Region) (ABIN310596)

Target: ATP1B1 (ATPase, Na+/K+ Transporting, beta 1 Polypeptide (ATP1B1))

Reactivity: Human, Mouse, Rat, Rabbit, Dog, Cow, Guinea Pig, Sheep, Horse, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ATP1B1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-ATP1B1 Antibody

Binding Specificity: Middle Region

Sequence: VMKYNPNVLP VQCTGKRDED KDKVGNVEYF GLGNSPGFPL QYYPYYGKLL

Predicted Reactivity: Cow: 92%, Dog: 86%, Guinea Pig: 85%, Horse: 86%, Human: 100%, Mouse: 100%, Pig: 92%, Rabbit: 92%, Rat: 100%, Sheep: 92%

Characteristics: This is a rabbit polyclonal antibody against ATP1B1. It was validated on Western Blot and immunohistochemistry.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human ATP1B1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 301 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for ATP1B1

Target: ATP1B1 (ATPase, Na+/K+ Transporting, beta 1 Polypeptide (ATP1B1))

Alternative Name: ATP1B1

Background: ATP1B1 belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 1 subunit.The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 1 subunit. Alternatively spliced transcript variants encoding different isoforms have been identified.
Alias Symbols: ATP1B, MGC1798
Protein Interaction Partner: Bace1, EGFR, ATP4A, UBC, BRCA1, BARD1, PAXIP1, GCH1, USP4, NEDD4L, ELAVL1, NDRG2, TRMT2A, DDAH2, HLA-DRB1, HLA-DRA, EZH2, CRIP2, KMT2B, PSME1, HLA-DRB5, HLA-DRB4, HLA-DRB3, LRIF1, FXYD7, FXYD1,
Protein Size: 301

Molecular Weight: 35 kDa

Gene ID: 481

NCBI Accession: NM_001001787, NP_001001787

UniProt: P05026

Pathways: Thyroid Hormone Synthesis, Ribonucleoside Biosynthetic Process, SARS-CoV-2 Protein Interactome