Prolyl 4-Hydroxylase, beta Polypeptide (P4HB) (C-Term) antibody

Details for Product No. ABIN310987
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Antigen
Synonyms CG6988, Dmel\\CG6988, Dpdi, EP(3)1022, PDI, dpdi, pdi, Pdi, Pdi2, mKIAA0994, DSI, ERBA2L, GIT, P4Hbeta, PDIA1, PHDB, PO4DB, PO4HB, PROHB, ERp59, Pdia1, Thbp, PDIR, p55, PDA2, PDIP, XPDIp
Epitope
C-Term
(14), (13), (4), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Rabbit, Mouse (Murine), Rat (Rattus), Cow (Bovine), Xenopus laevis, Human, Chicken
(92), (45), (40), (21), (13), (8), (7), (7), (5), (5), (4), (4), (3), (3), (2), (1), (1)
Host
Rabbit
(92), (23)
Clonality
Polyclonal
Conjugate
Un-conjugated
(10), (8), (7), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(88), (45), (31), (24), (23), (22), (15), (13), (10), (9), (4), (3), (1), (1), (1), (1)
Pubmed 1 reference available
Quantity 50 μg
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Catalog No. ABIN310987
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Immunogen Synthetic peptide directed towards the C terminal of human P4HB
Sequence DRTVIDYNGE RTLDGFKKFL ESGGQDGAGD DDDLEDLEEA EEPDMEEDDD
Predicted Reactivity Bovine : 100 %, Chicken : 100 %, Dog : 100 %, Human : 100 %, Mouse : 100 %, African clawed frog : 90 %
Characteristics This is a rabbit polyclonal antibody against P4HB. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name P4HB
Background P4HB is the beta subunit of prolyl 4-hydroxylase, a highly abundant multifunctional enzyme that belongs to the protein disulfide isomerase family. When present as a tetramer consisting of two alpha and two beta subunits, this enzyme is involved in hydroxylation of prolyl residues in preprocollagen. This enzyme is also a disulfide isomerase containing two thioredoxin domains that catalyze the formation, breakage and rearrangement of disulfide bonds. Other known functions include its ability to act as a chaperone that inhibits aggregation of misfolded proteins in a concentration-dependent manner, its ability to bind thyroid hormone, its role in both the influx and efflux of S-nitrosothiol-bound nitric oxide, and its function as a subunit of the microsomal triglyceride transfer protein complex.This gene encodes the beta subunit of prolyl 4-hydroxylase, a highly abundant multifunctional enzyme that belongs to the protein disulfide isomerase family. When present as a tetramer consisting of two alpha and two beta subunits, this enzyme is involved in hydroxylation of prolyl residues in preprocollagen. This enzyme is also a disulfide isomerase containing two thioredoxin domains that catalyze the formation, breakage and rearrangement of disulfide bonds. Other known functions include its ability to act as a chaperone that inhibits aggregation of misfolded proteins in a concentration-dependent manner, its ability to bind thyroid hormone, its role in both the influx and efflux of S-nitrosothiol-bound nitric oxide, and its function as a subunit of the microsomal triglyceride transfer protein complex.
Molecular Weight 55 kDa
Gene ID 5034
NCBI Accession NP_000909, NM_000918
UniProt P07237
Research Area Cancer, Extracellular Matrix
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 508 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
anti-Prolyl 4-Hydroxylase, beta Polypeptide (P4HB) (C-Term) antibody WB Suggested Anti-P4HB Antibody Titration: 0.2-1 ug/ml
Positive Control: HepG2 cell lysate
Product cited in: Ewing, Chu, Elisma et al.: "Large-scale mapping of human protein-protein interactions by mass spectrometry. ..." in: Molecular systems biology, Vol. 3, pp. 89, 2007 (PubMed).

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