G Protein-Coupled Receptor 119 (GPR119) antibody

Antigen: G Protein-Coupled Receptor 119 (GPR119)

Synonyms: GPCR2, hGPCR2, MGC119957, GPR119

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Western Blotting (WB)

Catalog no.: ABIN317642

Additional Information

Characteristics: Synonyms: G-protein coupled receptor 119, Glucose-dependent insulinotropic receptor

Alternative name: GPR119

Swiss-Prot: Q8TDV5

Cross-Reactivity: Human

Description: G protein-coupled receptors (GPRs) are a protein family of transmembrane receptors thattransmit an extracellular signal (ligand binding) into an intra cellular signal (G proteinactivation). GPR signaling is an evolutionarily ancient mechanism used by all eukaryotes tosense environmental stimuli and mediate cell-cell communication. All of the receptorshave seven membrane- spanning domains and the extracellular parts of the receptor canbe glycosylated. These extracellular loops also contain two highly conserved cysteineresidues which create disulfide bonds to stabilize the receptor structure. GPR119 is a 335amino acid protein that is mainly expressed in the pancreas. It is an endogenous receptorfor lysophosphatidylcholine (LPC), which is is a lipid mediator involved in insulin secretionfrom pancreatic ? cells. GPR119 may participate in this insulin secretion, suggesting that itmay be potential target for new anti-diabetic drugs.

Specificity: This antibody detects endogenous levels of GPR119 protein. Species: Human. Others not tested.

Application Details

Application Notes: ELISA: 1/1000-1/5000. Western Blot: 1/500-1/1000. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.

Concentration: 1.0 mg/ml

Purification: Aff - Purified

Buffer: Phosphate buffered saline (PBS), pH~7.2 containing 15 mM Sodium Azideas preservative.

Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: One year from despatch.

Research Area: Signaling, Receptors

Restrictions: For Research Use only