OB Cadherin antibody

Catalog No. ABIN317681

The Rabbit Polyclonal anti-OB Cadherin antibody is suitable to detect OB Cadherin in samples from Human and Mouse. It has been validated for WB.

Quick Overview for OB Cadherin antibody (ABIN317681)

Target: OB Cadherin (CDH11) (Cadherin 11 (CDH11))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This OB Cadherin antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-OB Cadherin Antibody

Specificity: This antibody detects endogenous levels of OB-Cadherin protein.(region surrounding Lys444)

Purification: Affinity Chromatography using epitope-specific immunogen.

Application Details

Application Notes: ELISA: 1/20000-1/40000. Western Blot: 1/500-1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH ~7.2 containing 0.05 % Sodium Azide as preservative.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for OB Cadherin

Target: OB Cadherin (CDH11) (Cadherin 11 (CDH11))

Alternative Name: Cadherin-11

Background: The cadherins are a family of Ca++-dependent adhesion molecules that function to mediate cell-cell binding critical to the maintenance of tissue structure and morphogenesis. Cadherins each contain a large extracellular domain at the amino terminus, which is characterized by a series of five homologous repeats, the most distal of which is thought to be responsible for binding specificity. The relatively short carboxy terminal, intracellular domain interacts with a variety of cytoplasmic proteins, including catenin beta, to regulate cadherin function. Two forms of OB-cadherin (for osteoblast-cadherin, also designated cadherin-11 or OSF-4) have been identified as OBcadherin- 1 and OB-cadherin-2. Both OB-cadherins are expressed in osteoblastic cell lines and low expression is also seen in lungs, testis and brain. OB-cadherin-2 has a truncated cytoplasmic domain.Synonyms: CDH11, OB Cadherin, OSF-4, Osteoblast cadherin

Molecular Weight: approx. 85 kDa

Gene ID: 1009

NCBI Accession: NP_001788

UniProt: P55287