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ITGA6 antibody

ITGA6 Reactivity: Human, Mouse, Dog, Pig, Monkey FACS, IP, IHC (fro) Host: Rat Monoclonal NKI-GoH3 unconjugated
Catalog No. ABIN319603
  • Target See all ITGA6 Antibodies
    ITGA6 (Integrin, alpha 6 (ITGA6))
    Reactivity
    • 119
    • 53
    • 25
    • 21
    • 16
    • 13
    • 9
    • 8
    • 7
    • 6
    • 6
    • 6
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Dog, Pig, Monkey
    Host
    • 71
    • 38
    • 17
    • 2
    Rat
    Clonality
    • 66
    • 60
    Monoclonal
    Conjugate
    • 70
    • 12
    • 11
    • 7
    • 6
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This ITGA6 antibody is un-conjugated
    Application
    • 80
    • 49
    • 47
    • 44
    • 23
    • 20
    • 13
    • 13
    • 13
    • 13
    • 10
    • 3
    • 3
    • 1
    Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Specificity
    The monoclonal antibody is directed against the CDw49f-antigen. This monoclonal NKI-GoH3 antibody reacts with platelets, megakaryocytes, T lymphocytes and common Acute Lymphoblastic Leukaemia cells (alpha-6 beta-1). In immunohistology the monoclonal antibody reacts with epithelial cells of a variety of tissues, peripheral nerves, microvascular endothelial cells, placenta cyto- and syncytiotrophoblasts. Platelet VLA-6 functions as a laminin receptor and platelet adhesion to laminin is inhibited by GoH3. Studies suggest that Clone NKI-GoH3 specifically blocks the binding of cells to the E8 fragment of laminin (See Sonnenberg, A. et al. for details).
    Purification
    Affinity Chromatography on Protein G
    Immunogen
    BALB/c mouse mammary tumour cells. Spleen cells from immunised Sprague-Dawley rats were fused with cells of the SP2/0 mouse myeloma cell line.
    Clone
    NKI-GoH3
    Isotype
    IgG2a
    Top Product
    Discover our top product ITGA6 Primary Antibody
  • Application Notes
    Flow cytometry. Immunohistochemistry on frozen sections. Recommended positive control: Human Tonsil. Immunoprecipitation.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    PBS, pH 7.4, 0.09 % Sodium Azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target
    ITGA6 (Integrin, alpha 6 (ITGA6))
    Alternative Name
    CD49f / ITGA6 (ITGA6 Products)
    Synonyms
    CD49f antibody, ITGA6B antibody, VLA-6 antibody, 5033401O05Rik antibody, AI115430 antibody, Cd49f antibody, ITGA6 antibody, inta6 antibody, im:6897425 antibody, itga6 antibody, si:dkey-32o22.1 antibody, wu:fb80g02 antibody, LOC100221694 antibody, si:dkey-18j14.1 antibody, wu:fl20e08 antibody, zgc:113088 antibody, integrin subunit alpha 6 antibody, integrin alpha 6 antibody, integrin subunit alpha 6 L homeolog antibody, integrin, alpha 6a antibody, integrin, alpha 6b antibody, ITGA6 antibody, Itga6 antibody, itga6.L antibody, itga6a antibody, itga6b antibody
    Background
    CDw49f-antigen is a 120kD, (GP Ic or VLA-6 alpha-chain), which can form distinct complexes with either the CD29-antigen (GP 11a or VLA beta-chain), resulting in the VLA-6 (alpha-6 beta-1) complex, which is expressed on human platelets, or with the beta-4 integrin resulting in the alpha-6 beta-4 complex which is expressed on various human epithelial cells.Synonyms: CD49 antigen-like family member F, Integrin alpha-6, VLA-6, VLA6
    Gene ID
    3655
    NCBI Accession
    NP_000201
    UniProt
    P23229
    Pathways
    CXCR4-mediated Signaling Events, Brown Fat Cell Differentiation, Integrin Complex
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