Coagulation Factor VIIa (FVIIa) antibody

Antigen: Coagulation Factor VIIa (FVIIa)

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Prothrombin Time (PT), Thrombin Generation Assay (TGA), Blocking Antibody (Inhibition), Indirect ELISA (iELISA)

Catalog no.: ABIN334633

Additional Information

Immunogen: recombinant human Factor VIIa (NovoSeven ® , Novo Nordisk A/S Denmark)

Format: Lyophilized

Description: Factor VIIa (FVIIa) is a key serine protease involved in the initiation of thecoagulation cascade. FVIIa requires tissue factor (TF), a membrane boundprotein, as an essential cofactor for maximal activity towards its biologicalsubstrates Factor X, Factor IX and Factor VII (FVII).

Specificity: Predicted reactivity: primates.

Application Details

Application Notes: Recommended Dilution 1: 15 000 (I-ELISA). Additional Information: no significant difference in binding to Factor VII and Factor VIIa .

Buffer: Affinity purified IgG in PBS pH 7.4

Storage: store lyophilized/reconstituted at -20°C, once reconstituted make aliquots to avoid repeated freeze-thaw cycles. Please, remember to spin tubes briefly prior toopening them, to avoid any losses that might occur from liquid material adheringto the cap or sides of the tubes.

Restrictions: For Research Use only

Publications

Publications: Xu, Zhao, Dinkins et al.: "The 73 kD subunit of the cleavage and polyadenylation specificity factor (CPSF) complex affects reproductive development in Arabidopsis." in: Plant molecular biology, Vol. 61, Issue 4 & 5, pp. 799-815, 2006 (PubMed).

Prins, van Heerden, Olmos et al.: "Cysteine proteinases regulate chloroplast protein content and composition in tobacco leaves: a model for dynamic interactions with ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco) vesicular bodies." in: Journal of experimental botany, Vol. 59, Issue 7, pp. 1935-50, 2008 (PubMed).