KCNJ8 antibody (Cytoplasmic Domain)

Catalog No. ABIN7699014

This Rabbit Polyclonal antibody specifically detects KCNJ8 in WB and IHC. It exhibits reactivity toward Human.

Quick Overview for KCNJ8 antibody (Cytoplasmic Domain) (ABIN7699014)

Target: KCNJ8 (Potassium Inwardly-Rectifying Channel, Subfamily J, Member 8 (KCNJ8))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KCNJ8 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-KCNJ8 Antibody

Binding Specificity: Cytoplasmic Domain

Purpose: Rabbit antibody to KCNJ8

Specificity: Specific for KCNJ8.

Cross-Reactivity: Human, Mouse, Rat

Cross-Reactivity (Details): Other species not yet tested.

Purification: IgG

Immunogen: A synthetic peptide from the cytoplasmic domain of human KCNJ8 conjugated to an immunogenic carrier protein was used as the antigen. The peptide is homologous in rat and mouse.

Isotype: IgG

Application Details

Application Notes: IHC WB. A concentration of 10-50,micro,g,ml is recommended. The optimal concentration should be determined by the end user. Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Reconstitute in 500 µl of sterile water. Centrifuge to remove any insoluble material.

Handling Advice: Avoid freeze and thaw cycles.

Storage: 4 °C,-20 °C

Storage Comment: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Expiry Date: 12 months

Target Details for KCNJ8

Target: KCNJ8 (Potassium Inwardly-Rectifying Channel, Subfamily J, Member 8 (KCNJ8))

Alternative Name: KCNJ8

Background: FUNCTION: This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium, as external potassium is raised the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium. Subcellular location: Membrane Multi-pass membrane protein.

UniProt: Q15842