CD2 antibody

Catalog No. ABIN356211

Product Details anti-CD2 Antibody

Target: CD2

Reactivity: Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This CD2 antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunoprecipitation (IP), Functional Studies (Func)

Specificity: This antibody is specific to CD2/LFA-2 (Mr 45-58 kDa)

Characteristics: Synonyms: T11/Leu-5, LFA-2, LFA-3 receptor, Erythrocyte receptor, Rosette receptor, SRBC, T-cellsurface antigen CD2, T-cell surface antigen T11/Leu-5

Purification: Purified

Clone: 01-12-15

Isotype: IgG1

Application Details

Application Notes: Flow Cytometry (Ref.1-3)Immunoprecipitation. (Ref.1-2)Functional Assay: In vitro Inhibition of CTL-mediated lysis. Induction of T cell unresponsiveness in vivo. (Ref.4)
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: 100 mM Borate Buffered Saline, pH 8.2. No preservatives or amine-containing buffer salts added.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for CD2

Target: CD2

Alternative Name: CD2 (CD2 Products)

Background: CD2, also known as leukocyte function-associated antigen-2 (LFA-2), is a member of the immunoglobulin superfamily of cell adhesion molecules. (Ref.1) It is expressed on the surface of >95 % of thymocytes, and essentially all B cells, T cells and NK cells. (Ref.1-3) In the mouse, CD2 is the receptor for CD48. (Ref.4) CD2 is thought to play a major role in mediating T-cell adhesion, T-cell recognition/activation, T-cell signaling and intrathymic differentiation. (Ref.5-10)Synonyms: Erythrocyte receptor, LFA-2, LFA-3 receptor, Rosette receptor, SRBC, T-cell surface antigen CD2, T-cell surface antigen T11/Leu-5

Gene ID: 12481

UniProt: P08920