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Non-SMC Condensin II Complex, Subunit H2 (NCAPH2) (N-Term) antibody

Details for Product No. ABIN357333
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Antigen
Synonyms MGC81656, CAPH2, si:dkey-202b22.2
Epitope
N-Term
(11), (2), (1)
Reactivity
Human
(16), (2), (2), (2), (1)
Host
Rabbit
(18)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB)
(16), (8), (3), (3), (2)
Pubmed 3 references available
Quantity 0.4 mL
Shipping to United States (Change)
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Catalog No. ABIN357333
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Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human NCAPH2.
Specificity This antibody detects NCAPH2 at N-term.
Purification Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
Alternative Name NCAPH2
Background Structural maintenance of chromosomes (SMC) and non-SMC condensin proteins associate into complexes that have been implicated in the process of chromosome condensation. A crucial prerequisite for accurate segregation of replicated sister chromatids is the condensation of the chromosomes into a manageable form prior to metaphase. The condensin I complex consists of two SMC subunits, SMC2 and SMC4, and three non-SMC subunits, CAP-H, CAP-G, and CAP-D2. An alternative complex, the condensin II complex, contains alternate non-SMC subunits, CAP-G2, CAP-H2, and CAP-D3. CAP-H2 is also known as Non-SMC condensin II complex, subunit H2 (NCAPH2) or kleisin beta isoform 2. The three non-SMC subunits in the condensing complexes form a regulatory subcomplex that is required to activate the SMC ATPases and to promote mitosis-specific chromatin binding of the holocomplex. The precise individual functions of each non-SMC protein in activation remain to be determined.
Alternate names: CAPH2, Chromosome-associated protein H2
Molecular Weight 62463 Da
Gene ID 29781
NCBI Accession NP_001171940.1
UniProt Q6IBW4
Research Area Chromatin and Nuclear Signaling, Cell Cycle
Application Notes ELISA 1: 1,000. Western blot 1: 100 - 1: 500. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09% (w/v) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer.
Expiry Date 12 months
Supplier Images
anti-Non-SMC Condensin II Complex, Subunit H2 (NCAPH2) (N-Term) antibody anti-Non-SMC Condensin II Complex, Subunit H2 (NCAPH2) (N-Term) antibody
Background publications Loftus, Kim, Sneddon et al.: "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q." in: Genomics, Vol. 60, Issue 3, pp. 295-308, 1999 (PubMed).

Schleiffer, Kaitna, Maurer-Stroh et al.: "Kleisins: a superfamily of bacterial and eukaryotic SMC protein partners." in: Molecular cell, Vol. 11, Issue 3, pp. 571-5, 2003 (PubMed).

Ono, Losada, Hirano et al.: "Differential contributions of condensin I and condensin II to mitotic chromosome architecture in vertebrate cells." in: Cell, Vol. 115, Issue 1, pp. 109-21, 2003 (PubMed).

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