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TRAF2 and NCK Interacting Kinase (TNIK) (pSer764) antibody

Details for Product No. ABIN358244, Supplier: Login to see
Antigen
  • TNIK
  • 1500031A17Rik
  • 4831440I19Rik
  • AI451411
  • C530008O15Rik
  • C630040K21Rik
  • RGD1561817
Epitope
pSer764
36
21
18
17
16
14
6
5
4
2
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
153
37
30
2
2
2
1
1
Host
Rabbit
148
7
Clonality
Polyclonal
Conjugate
Un-conjugated
12
12
12
10
10
10
3
2
2
2
2
2
2
2
2
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
84
66
65
32
24
22
7
4
3
2
2
1
1
1
1
Supplier
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Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S764 of human TNIK.
Isotype Ig
Specificity This antibody detects TNIK pSer764.
Purification Protein G Affinity Chromatography. Then, the antibody fraction is peptide affinity purified in a 2-step procedure with control and phosphorylated peptides. The phospho-specific antibody is eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name TNIK (TNIK Antibody Abstract)
Background TNIK is a stress-activated serine/threonine kinase that may play a role in the response to environmental stress. This protein appears to act upstream of the JUN N-terminal pathway, and may play a role in cytoskeletal regulation.Synonyms: KIAA0551, TRAF2 and NCK-interacting protein kinase
Molecular Weight 154943 Da
Gene ID 23043, 9606
UniProt Q9UKE5
Research Area Signaling, Extracellular Matrix, Kinases/Phosphatases
Pathways
Application Notes ELISA: 1/1,000. Immunohistochemistry: 1/50-1/100. Dot Blot: 1/100-1/500.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) Sodium Azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
Supplier Images
 image for anti-TRAF2 and NCK Interacting Kinase (TNIK) (pSer764) antibody (ABIN358244) anti-TRAF2 and NCK Interacting Kinase (TNIK) (pSer764) antibody
 image for anti-TRAF2 and NCK Interacting Kinase (TNIK) (pSer764) antibody (ABIN358244) anti-TRAF2 and NCK Interacting Kinase (TNIK) (pSer764) antibody (Image 2)
Background publications Taira, Umikawa, Takei et al.: "The Traf2- and Nck-interacting kinase as a putative effector of Rap2 to regulate actin cytoskeleton." in: The Journal of biological chemistry, Vol. 279, Issue 47, pp. 49488-96, 2004 (PubMed).

Fu, Shen, Huang et al.: "TNIK, a novel member of the germinal center kinase family that activates the c-Jun N-terminal kinase pathway and regulates the cytoskeleton." in: The Journal of biological chemistry, Vol. 274, Issue 43, pp. 30729-37, 1999 (PubMed).

Yonekura, Migita, Sakurai et al.: "Antisense display--a method for functional gene screening: evaluation in a cell-free system and isolation of angiogenesis-related genes." in: Nucleic acids research, Vol. 27, Issue 13, pp. 2591-600, 1999 (PubMed).