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TRAF2 and NCK Interacting Kinase (TNIK) (pSer764) antibody

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Synonyms TNIK, 1500031A17Rik, 4831440I19Rik, AI451411, C530008O15Rik, C630040K21Rik, RGD1561817
(36), (21), (18), (17), (16), (14), (6), (5), (4), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
(153), (37), (30), (2), (2), (2), (1), (1)
(148), (7)
(12), (12), (12), (10), (10), (10), (3), (2), (2), (2), (2), (2), (2), (2), (2)
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(84), (66), (65), (32), (24), (22), (7), (4), (3), (2), (2), (1), (1), (1), (1)
Pubmed 3 references available
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Quantity 0.4 mL
Shipping to United States ( )
Availability Will be delivered in 6 to 8 Business Days
Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S764 of human TNIK.
Isotype Ig
Specificity This antibody detects TNIK pSer764.
Purification Protein G Affinity Chromatography. Then, the antibody fraction is peptide affinity purified in a 2-step procedure with control and phosphorylated peptides. The phospho-specific antibody is eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name TNIK (TNIK Antibody Abstract)
Background TNIK is a stress-activated serine/threonine kinase that may play a role in the response to environmental stress. This protein appears to act upstream of the JUN N-terminal pathway, and may play a role in cytoskeletal regulation.Synonyms: KIAA0551, TRAF2 and NCK-interacting protein kinase
Molecular Weight 154943 Da
Gene ID 23043, 9606
UniProt Q9UKE5
Research Area Signaling, Extracellular Matrix, Kinases/Phosphatases
Application Notes ELISA: 1/1,000. Immunohistochemistry: 1/50-1/100. Dot Blot: 1/100-1/500.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) Sodium Azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
Supplier Images
 image for anti-TRAF2 and NCK Interacting Kinase (TNIK) (pSer764) antibody (ABIN358244) anti-TRAF2 and NCK Interacting Kinase (TNIK) (pSer764) antibody
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Background publications Taira, Umikawa, Takei et al.: "The Traf2- and Nck-interacting kinase as a putative effector of Rap2 to regulate actin cytoskeleton." in: The Journal of biological chemistry, Vol. 279, Issue 47, pp. 49488-96, 2004 (PubMed).

Fu, Shen, Huang et al.: "TNIK, a novel member of the germinal center kinase family that activates the c-Jun N-terminal kinase pathway and regulates the cytoskeleton." in: The Journal of biological chemistry, Vol. 274, Issue 43, pp. 30729-37, 1999 (PubMed).

Yonekura, Migita, Sakurai et al.: "Antisense display--a method for functional gene screening: evaluation in a cell-free system and isolation of angiogenesis-related genes." in: Nucleic acids research, Vol. 27, Issue 13, pp. 2591-600, 1999 (PubMed).

Catalog No. ABIN358244
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