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tyrosine Kinase, Non-Receptor, 2 (TNK2) (pTyr518) antibody

Details for Product No. ABIN358513, Supplier: Login to see
Antigen
  • ACK
  • ACK-1
  • ACK1
  • p21cdc42Hs
  • AW552477
  • Ack
  • Cdgip
  • Pyk1
Epitope
pTyr518
31
22
19
15
15
14
14
12
11
9
7
7
6
6
5
5
4
3
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
181
67
54
4
3
2
Host
Rabbit
179
2
2
Clonality
Polyclonal
Conjugate
Un-conjugated
12
10
10
9
8
8
3
2
2
2
2
2
2
2
2
Application
Enzyme Immunoassay (EIA)
115
96
41
36
23
18
18
9
7
5
5
2
1
Supplier
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Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y518 of human ACK1.
Isotype Ig
Specificity This antibody detects TNK2 / ACK1 pTyr518.
Purification Protein A Chromatography followed by two-step phosphospecific peptide affinity purification.
Alternative Name TNK2 / ACK1 (TNK2 Antibody Abstract)
Background ACK1 is a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway.Synonyms: Activated CDC42 kinase 1
Molecular Weight 114327 Da
Gene ID 10188, 9606
UniProt Q07912
Pathways
Application Notes ELISA: 1/1,000. Dot Blot: 1/500.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) Sodium Azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
Supplier Images
 image for anti-tyrosine Kinase, Non-Receptor, 2 (TNK2) (pTyr518) antibody (ABIN358513) anti-tyrosine Kinase, Non-Receptor, 2 (TNK2) (pTyr518) antibody
Background publications Rikova, Guo, Zeng et al.: "Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. ..." in: Cell, Vol. 131, Issue 6, pp. 1190-203, 2007 (PubMed).

Wolf-Yadlin, Hautaniemi, Lauffenburger et al.: "Multiple reaction monitoring for robust quantitative proteomic analysis of cellular signaling networks." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 14, pp. 5860-5, 2007 (PubMed).

Cohen: "Varicella-zoster vaccine virus: evolution in action." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 1, pp. 7-8, 2007 (PubMed).

Goss, Lee, Moritz et al.: "A common phosphotyrosine signature for the Bcr-Abl kinase." in: Blood, Vol. 107, Issue 12, pp. 4888-97, 2006 (PubMed).