OASL antibody (C-Term)

Catalog No. ABIN358720

This Rabbit Polyclonal antibody specifically detects OASL in WB, IHC (p) and EIA. It exhibits reactivity toward Human.

Quick Overview for OASL antibody (C-Term) (ABIN358720)

Target: OASL (2'-5'-Oligoadenylate Synthetase-Like (OASL))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This OASL antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Product Details anti-OASL Antibody

Binding Specificity: C-Term

Specificity: This antibody reacts to OASL.

Purification: Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS

Immunogen: This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human OASL.

Isotype: Ig Fraction

Application Details

Application Notes: ELISA: 1/1,000. Western blotting: 1/100 - 1/500. Immunohistochemistry: 1/50 - 1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Target Details for OASL

Target: OASL (2'-5'-Oligoadenylate Synthetase-Like (OASL))

Background: 2-prime,5-prime oligoadenylates (2-5As) bind to and activate RNase L, leading to degradation of RNA and inhibition of protein synthesis. 2-5As are produced by 2-5A synthetases (OASs), a highly-conserved family of interferon-induced enzymes. The predicted 514-amino acid human p59OASL (2-5A synthetases-like) protein shares a highly conserved N-terminal domain with other OASs. The C-terminal portion of p59OASL contains 2 ubiquitin-like domains. p59OASL is expressed in most tissues, with the highest levels in hematopoietic tissues, colon, and stomach.Synonyms: 59 kDa 2'-5'-oligoadenylate synthetase-like protein, TR-interacting protein 14, Thyroid receptor-interacting protein 14, p59 OASL

Gene ID: 8638, 9606

UniProt: Q15646