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CD31 antibody (Platelet/endothelial Cell Adhesion Molecule) (C-Term)

Details for Product anti-PECAM1 Antibody No. ABIN359628, Supplier: Login to see
Antigen
  • CD31
  • CD31/EndoCAM
  • GPIIA'
  • PECA1
  • PECAM-1
  • endoCAM
  • C85791
  • Cd31
  • Pecam
Epitope
C-Term
59
16
14
13
9
9
6
5
5
5
5
5
5
5
4
4
4
3
3
3
3
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
618
268
110
53
19
17
16
15
15
10
5
4
3
1
Host
Rabbit
561
194
154
8
8
1
Clonality
Polyclonal
Conjugate
This CD31 antibody is un-conjugated
103
77
76
39
12
10
9
7
6
5
4
4
3
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
541
319
242
161
154
145
118
81
31
22
13
11
11
11
10
10
8
5
5
3
3
3
2
2
2
1
1
1
1
1
1
Supplier
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Immunogen This CD31 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human CD31.
Isotype Ig
Specificity This antibody recognizes CD31.
Purification Prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS
Alternative Name CD31 / PECAM1 (PECAM1 Antibody Abstract)
Background CD31, also known as platelet endothelial cell adhesion molecule 1 (PECAM1), is a type I integral membrane glycoprotein and a member of the immunoglobulin superfamily of cell surface receptors. It is constitutively expressed on the surface of endothelial cells, and concentrated at the junction between them. It is also weakly expressed on many peripheral lymphoid cells and platelets. CD31 has been used to measure angiogenesis in association with tumor recurrence. Other studies have also indicated that CD31 and CD34 can be used as markers for myeloid progenitor cells and recognize different subsets of myeloid leukemia infiltrates (granular sarcomas). CD31 is a cell adhesion molecule expressed on platelets and at endothelial cell intercellular junctions.Synonyms: End °CAM, GPIIA', PECAM-1, Platelet endothelial cell adhesion molecule
Gene ID 5175, 9606
UniProt P16284
Research Area CD Antigens, Surface Receptors of Immune Cells
Pathways
Application Notes ELISA: 1/1,000. Western blotting: 1/50-1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
Supplier Images
Western Blotting (WB) image for anti-CD31 antibody (Platelet/endothelial Cell Adhesion Molecule) (C-Term) (ABIN359628) Western blot analysis of CD31 antibody (C-term) in HL60 cell line lysates (35ug/lane)...
Background publications Simmons, Walker, Power et al.: "Molecular cloning of CD31, a putative intercellular adhesion molecule closely related to carcinoembryonic antigen." in: The Journal of experimental medicine, Vol. 171, Issue 6, pp. 2147-52, 1990 (PubMed).

Stockinger, Gadd, Eher et al.: "Molecular characterization and functional analysis of the leukocyte surface protein CD31." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 145, Issue 11, pp. 3889-97, 1991 (PubMed).

Newman, Berndt, Gorski et al.: "PECAM-1 (CD31) cloning and relation to adhesion molecules of the immunoglobulin gene superfamily." in: Science (New York, N.Y.), Vol. 247, Issue 4947, pp. 1219-22, 1990 (PubMed).