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beta-Site APP-Cleaving Enzyme 1 (BACE) (N-Term) antibody

Details for Product No. ABIN360082, Supplier: Log in to see
Antigen
  • BACE1
  • MGC145931
  • bace2
  • MGC68881
  • MGC68482
  • BACE2
  • C76936
  • Bace
  • ASP2
  • BACE
  • HSPC104
  • zgc:77409
Epitope
N-Term
30
20
19
13
10
7
5
5
5
3
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine)
181
82
58
6
3
2
2
2
1
1
1
1
1
1
1
1
Host
Rabbit
177
11
5
Clonality
Polyclonal
Conjugate
Un-conjugated
7
6
3
3
2
2
2
2
2
2
2
2
2
2
2
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
118
74
46
39
22
15
9
9
7
4
3
2
2
2
1
Supplier
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Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human BACE1.
Isotype Ig
Specificity This antibody reacts to BACE1.
Purification Prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS
Alternative Name BACE1 (BACE Antibody Abstract)
Background Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is BACE. This protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi.Synonyms: ASP2, Aspartyl protease 2, BACE, BACE-1, Beta-secretase 1, Beta-site APP cleaving enzyme 1, Beta-site amyloid precursor protein cleaving enzyme 1, KIAA1149, Memapsin-2, Membrane-associated aspartic protease 2
Gene ID 23621, 9606
UniProt P56817
Research Area Proteolysis / Ubiquitin, Alzheimer's Disease, Enzymes
Pathways
Application Notes ELISA: 1/1,000. Western blot: 1/50 - 1/100. Immunohistochemistry on paraffin sections: 1/10 - 1/50.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
Supplier Images
 image for anti-beta-Site APP-Cleaving Enzyme 1 (BACE) (N-Term) antibody (ABIN360082) anti-beta-Site APP-Cleaving Enzyme 1 (BACE) (N-Term) antibody
 image for anti-beta-Site APP-Cleaving Enzyme 1 (BACE) (N-Term) antibody (ABIN360082) anti-beta-Site APP-Cleaving Enzyme 1 (BACE) (N-Term) antibody (Image 2)
Background publications Xie, Guo: "PAR-4 is involved in regulation of beta-secretase cleavage of the Alzheimer amyloid precursor protein." in: The Journal of biological chemistry, Vol. 280, Issue 14, pp. 13824-32, 2005 (PubMed).

He, Li, Chang et al.: "GGA proteins mediate the recycling pathway of memapsin 2 (BACE)." in: The Journal of biological chemistry, Vol. 280, Issue 12, pp. 11696-703, 2005 (PubMed).