PIK3CD (C-Term) antibody

Details for Product No. ABIN360448
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Antigen
Synonyms PI3K, p110D, P110DELTA, AW545373, p110delta, 2410099E07Rik, 2610208K16Rik
Epitope
C-Term
(17), (3), (3), (3), (2), (2), (1), (1), (1), (1)
Reactivity
Human
(54), (27), (24), (12), (12), (12), (12)
Host
Rabbit
(50), (4)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Application
ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(26), (22), (20), (16), (7), (6), (2), (2), (1)
Pubmed 2 references available
Catalog no. ABIN360448
Quantity 0.4 mL
Price
357.50 $   Plus shipping costs $45.00
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Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human PI3KCD.
Specificity This antibody reacts to PI3KCD.
Purification Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
Background Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains.
Alternate names: 5-bisphosphate 3-kinase catalytic subunit delta isoform, PI3-kinase subunit delta, PI3K- delta, Phosphatidylinositol-4, PtdIns-3-kinase subunit delta, PtdIns-3-kinase subunit p110-delta
Gene ID 5293
NCBI Accession 9606
UniProt O00329
Application Notes ELISA: 1/1,000. Western blotting: 1/100 - 1/500. Immunohistochemistry: 1/50 - 1/100. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09% (w/v) sodium azide
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at-20°C for longer.
Expiry Date 12 months
Supplier Images
anti-PIK3CD (C-Term) antibody anti-PIK3CD (C-Term) antibody
anti-PIK3CD (C-Term) antibody (2) anti-PIK3CD (C-Term) antibody (Image 2)
Background publications Vanhaesebroeck, Welham, Kotani et al.: "P110delta, a novel phosphoinositide 3-kinase in leukocytes." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 9, pp. 4330-5, 1997 (PubMed).

Chantry, Vojtek, Kashishian et al.: "p110delta, a novel phosphatidylinositol 3-kinase catalytic subunit that associates with p85 and is expressed predominantly in leukocytes." in: The Journal of biological chemistry, Vol. 272, Issue 31, pp. 19236-41, 1997 (PubMed).

Hosts (50), (4)
Reactivities (54), (27), (24), (12), (12), (12), (12)
Applications (26), (22), (20), (16), (7), (6), (2), (2), (1)
Conjugates (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Epitopes (17), (3), (3), (3), (2), (2), (1), (1), (1), (1)
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