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PIK3CD (C-Term) antibody

Details for Product No. ABIN360448, Supplier: Login to see New
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Synonyms 2410099E07Rik, 2610208K16Rik, AW545373, p110delta, P110DELTA, PI3K, p110D
(31), (19), (17), (13), (12), (8), (6), (6), (6), (6), (3), (2), (1), (1), (1), (1), (1), (1)
(116), (33), (31)
(108), (9)
(10), (10), (10), (8), (8), (8), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(67), (41), (33), (32), (22), (11), (5), (4), (3), (1), (1)
Pubmed 2 references available
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Quantity 0.4 mL
Shipping to United States ( )
Availability Will be delivered in 6 to 8 Business Days
Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human PI3KCD.
Isotype Ig
Specificity This antibody reacts to PI3KCD.
Purification Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
Background Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains.Synonyms: 5-bisphosphate 3-kinase catalytic subunit delta isoform, PI3-kinase subunit delta, PI3K-delta, Phosphatidylinositol-4, PtdIns-3-kinase subunit delta, PtdIns-3-kinase subunit p110-delta
Gene ID 5293, 9606
UniProt O00329
Application Notes ELISA: 1/1,000. Western blotting: 1/100 - 1/500. Immunohistochemistry: 1/50 - 1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
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Background publications Chantry, Vojtek, Kashishian et al.: "p110delta, a novel phosphatidylinositol 3-kinase catalytic subunit that associates with p85 and is expressed predominantly in leukocytes." in: The Journal of biological chemistry, Vol. 272, Issue 31, pp. 19236-41, 1997 (PubMed).

Vanhaesebroeck, Welham, Kotani et al.: "P110delta, a novel phosphoinositide 3-kinase in leukocytes." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 9, pp. 4330-5, 1997 (PubMed).

Catalog No. ABIN360448
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