Retinoid X Receptor, (-Isotype antibody

Antigen: Retinoid X Receptor, (-Isotype

Clonality: Monoclonal (147)

Host: Mouse

Reactivity: Mouse (Murine), Rat (Rattus)

Application: Western Blotting (WB)

Catalog no.: ABIN361387

Additional Information

Format: Affinity-purified

Isotype: IgG1  (Matching secondary antibodies)

Clone: 147

Description: Retinoic acid (RA, active metabolite of vitamin A) plays a prominent role in regulating the transition of proliferating precursor cells (such as carcinoma cells and neuronal precursors) to postmitotic differentiated cells (Joshi et al., 2005). The retinoid X receptors (RXRs) family (RXRa, ß and (), preferentially bind 9-cis-RA and regulate gene transcription by forming heterodimers with a second family of RA receptors. RAs have been suggested to potentially play a therapeutic role in cervical cancer (Abu et al., 2005). RAs are known to play key roles in neuronal development and an increasing body of evidence indicates that retinoid signaling may regulate synaptic plasticity and associated learning and memory behaviors (Lane and Bailey, 2005). Anti-Human Retinoid X Receptor Antibody, (-Isotype Western blot of hippocampal lysate showing specific immunolabeling of the ~48k RXR-ß protein.

Specificity: Specific for the ~48k RXR-( protein.

Application Details

Application Notes: Recommended Dilution: WB: 1:1000 Quality Control: Western blots performed on each lot.

Purification: Prepared from mouse ascites by ammonium sulfate precipitation followed by affinity purification on a protein G column.

Storage: Store at -20 °C, stable for 1 year

Restrictions: For Research Use only

Images

Western blots of hippocampal lysate showing specific immunolabeling of the ~48k RXR-ß protein.