Heat Shock 10kDa Protein 1 (Chaperonin 10) (HSPE1) antibody

Antigen: Heat Shock 10kDa Protein 1 (Chaperonin 10) (HSPE1)

Synonyms: CPN10, GROES, HSP10, groS, Cpn10, cpn10, zgc:86747, HSPE1, MGC79030, hspe1, MGC89647, CHLOROPLAST CHAPERONIN 10, F16B22.14, ATCPN21, CHAPERONIN 10, CHAPERONIN 20, CHCPN10, CPN20, CPN21, T1M15.120, T1M15_120, MITOCHONDRIAL CHAPERONIN 10, T15D22.2, T15D22_2, anon-WO0118547.175, DmelCG11267, Hsp10, hsp10, crpB, chpS

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human, Mouse (Murine), Rat (Rattus), Cow (Bovine), Dog (Canine), Guinea Pig, Pig (Porcine), Rabbit, Sheep (Ovine), Xenopus laevis

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC), ELISA

Catalog no.: ABIN361677

Additional Information

Alternative name: cpn10

Immunogen: Human Cpn10 peptide amino acids 91-101

Format: Protein A purified

Description: Chaperonin 10, otherwise known as Cpn10, (groES in E.coli) make up a family of small heart shock proteins with an approximate molecular mass of 10kDa (Hsp10s). Cpn10 acts as a co-chaperone and interacts with the Hsp60 family to promote proper folding of polypeptides. Cpn10 and Cpn60 both exhibit sevenfold axis of symmetry and function as a team in the protein folding and assembly process (1). Cpn10 has been located in human platelets, but is also present in human maternal serum (2, 3). It has been reported that human Cpn10 is identical with early pregnancy factor, which is involved in control over cell growth and development. This identification suggest that Cpn10 may act like a hormone in stressful situations such as pregnancy (4).

Specificity: ~10kDa Species Cross-reactivity Human, Mouse, Rat, Bovine, Canine, Guinea pig, Pig, Rabbit, Sheep, Xenopus

Synonyms: CPN10, GROES, HSP10, groS, Cpn10, cpn10, zgc:86747, HSPE1, MGC79030, hspe1, MGC89647, CHLOROPLAST CHAPERONIN 10, F16B22.14, ATCPN21, CHAPERONIN 10, CHAPERONIN 20, CHCPN10, CPN20, CPN21, T1M15.120, T1M15_120, MITOCHONDRIAL CHAPERONIN 10, T15D22.2, T15D22_2, anon-WO0118547.175, DmelCG11267, Hsp10, hsp10, crpB, chpS

Application Details

Application Notes: 1:1000 for WB

Concentration: 1mg/mL

Buffer: In PBS with 0.02% NaN3, pH7.3, Protein A purified

Storage: -20°C, 1 year+, shipped on cold packs

Restrictions: For Research Use only

Images

Cpn10, Rat brain extract

Publications

Publications: Morton, Hegh, Clunie: "Immunosuppression detected in pregnant mice by rosette inhibition test." in: Nature, Vol. 249, Issue 456, pp. 459-60, 1974 (PubMed).

Vuelez-Granell, Arias, Torres-Ruuiz et al.: "Molecular chaperones in pancreatic tissue: the presence of cpn10, cpn60 and hsp70 in distinct compartments along the secretory pathway of the acinar cells." in: Journal of cell science, Vol. 107 ( Pt 3), pp. 539-49, 1994 (PubMed).

Cavanagh, Morton: "The purification of early-pregnancy factor to homogeneity from human platelets and identification as chaperonin 10." in: European journal of biochemistry / FEBS, Vol. 222, Issue 2, pp. 551-60, 1994 (PubMed).

Minto, Galli, Gianazza et al.: "Mycobacterial Cpn10 promotes recognition of the mammalian homologue by a mycobacterium-specific antiserum." in: Biochimica et biophysica acta, Vol. 1403, Issue 2, pp. 151-7, 1998 (PubMed).