Potassium Inwardly-Rectifying Channel, Subfamily J, Member 2 (KCNJ2) antibody

Antigen: Potassium Inwardly-Rectifying Channel, Subfamily J, Member 2 (KCNJ2)

Synonyms: IRK1, LQT7, SQT3, HHIRK1, KIR2.1, HHBIRK1, Kcnf1, Kir2.1

Clonality: Monoclonal (S112B-14)

Host: Mouse

Reactivity: Human, Mouse (Murine), Rat (Rattus)

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Catalog no.: ABIN361769

Additional Information

Characteristics: Detects ~45kDa. No cross-reactivity against Kir2.2 or Kir2.3

Alternative name: Kir2.1

Gene ID: 16518

Swiss-Prot: P35561

Immunogen: Fusion protein amino acids 41-64 and 189-428 of mouse Kir2.1, accession number NP_032451.

Format: Liquid

Isotype: IgG1  (Matching secondary antibodies)

Clone: S112B-14

Description: The Kir2.1 inward-rectifier potassium ion channel is encoded by the KCNJ2 gene. A defect in this gene is associated with Andersen-Tawil syndrome.
Synonyms: HHBIRK1, HHIRK1, HIRK 1, IRK1, KCNJ2, LQT7, SQT3, potassium inwardly rectifying channel J2

Specificity: ~55kDa. No cross reactivity against Kir2.2, or Kir2.3. Species cross-reactivity: Human, Mouse, Rat.

Sensitivity: 1 µg/mL of SMC-310 was sufficient for detection of Kir2.1 in 10µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

Application Details

Application Notes: 1-10ug/mL (WB), 0.1-1.0ug/mL (Perox) (IHC/ICC), 1.0-10ug/mL (IF)

Concentration: 1 mg/mL

Purification: Protein G purified

Buffer: PBS pH7.4, 50% glycerol

Storage: -20 °C

Storage Shipping Temp Max: Blue Ice or 4 °C

Restrictions: For Research Use only

Images

Kir2.1 (S21-32), Human hippocampus

Publications

Publications: Donaldson, Yoon, Fu et al.: "Andersen-Tawil syndrome: a model of clinical variability, pleiotropy, and genetic heterogeneity." in: Annals of medicine, Vol. 36 Suppl 1, pp. 92-7, 2004 (PubMed).