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|+1 888 205 9894 (TF)|
Acetylated Lysine (acLys) antibody
Cow (Bovine), Bird (Avian)
Alternatives Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
|4 references available|
|Price||196.90 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 3 to 4 Business Days|
Post-translational modifications of proteins play critical roles in the regulation and function of many known biological processes. Proteins can be post-translationally modified in many different ways, and a common post-transcriptional modification of Lysine involves acetylation. The conserved amino-terminal domains of the four core histones (H2A, H2B, H3 and H4) contain lysines that are acetylated by histone acetyltransferases (HATs) and deacetylated by histone deacetylases (HDACs). Protein posttranslational reversible lysine Nepsilon development.
Synonyms: lysine, acetyl lysine
|Specificity||Detects proteins containing acetylated lysine residues in ELISA and WBs. Does not detect non-acetylated lysine residues.|
|Sensitivity||1µg of SMC-153 was sufficient to detect acetylated chicken erythrocyte histones (sodium butyrate-treated) using 20µg total protein, on western blot by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.|
|Purification||Protein G purified|
|Buffer||PBS pH7.4, 50% glycerol|
|Storage||Store at -20° C. Shipping Conditions: Blue Ice or 4° C|
|Storage Shipping Temp Max||Blue Ice or 4 °C|
|Research Area||Cell Signaling|
|Restrictions||For Research Use only|
|Acetylated Lysine (7F8), mouse backskin|
Hughes: "Polyglutamine disease: acetyltransferases awry." in: Current biology : CB, Vol. 12, Issue 4, pp. R141-3, 2002 (PubMed).
Vigushin, Coombes: "Targeted histone deacetylase inhibition for cancer therapy." in: Current cancer drug targets, Vol. 4, Issue 2, pp. 205-18, 2004 (PubMed).
Yang: "Lysine acetylation and the bromodomain: a new partnership for signaling." in: BioEssays : news and reviews in molecular, cellular and developmental biology, Vol. 26, Issue 10, pp. 1076-87, 2004 (PubMed).
Yang: "Multisite protein modification and intramolecular signaling." in: Oncogene, Vol. 24, Issue 10, pp. 1653-62, 2005 (PubMed).
|Hosts||Mouse (13), Rabbit (13)|
|Reactivities||Bird (Avian) (5), Cow (Bovine) (4), All Species (3), Chicken (1), Human (1), Mammalian (1)|
|Applications||Western Blotting (WB) (26), ELISA (22), Immunoprecipitation (IP) (9), Immunofluorescence (IF) (8), Immunohistochemistry (IHC) (6), Immunocytochemistry (ICC) (4), Immunohistochemistry (Frozen Sections) (IHC (fro)) (2), Enzyme Immunoassay (EIA) (1)|
|Conjugates||Biotin (4), HRP (4)|