Add to Basket
Order hotline:
 |
+1 404 474 4654 |
 |
+1 888 205 9894 (TF) |
Prolyl 4-Hydroxylase, beta Polypeptide (P4HB) antibody
| Antigen | Prolyl 4-Hydroxylase, beta Polypeptide (P4HB) |
| Synonyms | DSI, GIT, PDI, PHDB, PDIA1, PO4DB, PO4HB, PROHB, ERBA2L, P4Hbeta, Thbp, ERp59, Pdia1, PDIR, LOC100328595, p55, P4HB, DKFZp469E2031 |
| Clonality | Polyclonal |
| Host |
 Alternatives Rabbit |
| Reactivity |
Alternatives Human, Mouse (Murine), Guinea Pig, Dog (Canine), Hamster, Monkey, Cow (Bovine), Sheep (Ovine), Pig (Porcine), Xenopus laevis |
| Application |
Alternatives Western Blotting (WB), Immunoprecipitation (IP), Immunocytochemistry (ICC), Immunohistochemistry (IHC)
|
| Catalog no. | ABIN361829 |
| Quantity | 100myl (Variants) |
| Price | 329.00 $ Plus shipping costs $35.00 |
| Shipping to |
|
| Availability | Ships within 7 to 10 Business Days |
Additional Information
| Characteristics | Detects ~58kDa. |
| Alternative name | PDI |
| Gene ID | NP_001099245.2, 287164 |
| Immunogen | Rat PDI synthetic peptide conjugated to KLH |
| Format | Liquid |
| Description |
The three dimensional structure of many extracellular proteins is stabilized by the formation of disulphide bonds. Studies suggest that a microsomal enzyme known as Protein Disulphide Isomerase (PDI) is involved in disulphide-bond formation via its oxidase activity and isomerization via its isomerase activity, as well as the reduction of disulphide bonds in proteins (1). Studies suggest BiP and PDI work together sequentially to increase oxidation of these proteins (2, 3). PDI has also been found to function as a chaperone to prevent the aggregation of unfolded substrates, and serves as a subunit of prolyl 4-hydroxylase and microsomal triglyceride transferase (4, 5). PDI is an abundant 55kDa protein located primarily in the ER, however studies have also proved its presence in the cytosol (1). PDI has the ability to reside in the ER permanently due to the highly conserved KDEL sequence at its carboxy-terminus (6). It uses carboxy-terminal KDEL as a retention signal, and this appears to be sufficient to reduce the secretion of proteins from the ER. This retention is reported to be mediated by a KDEL receptor (7). Synonyms: PDA2, PDI, PDIA2, PDIP, pancreatic protein disulfide isomerase |
| Specificity | Detects ~58kDa. Species cross-reactivity: Human, Mouse, Rat, Dog, Hamster, Monkey, Guinea Pig, Bovine, Sheep, Pig, Xenopus. |
Application Details
| Application Notes | Working Dilution WB 1:4000 (ECL) |
| Purification | Antiserum |
| Storage | -20 °C |
| Storage Shipping Temp Max | Blue Ice or 4 °C |
| Research Area | Heat Shock Proteins, Organelles |
| Restrictions | For Research Use only |
Alternatives
Alternatives for antigen "Prolyl 4-Hydroxylase, beta Polypeptide (P4HB)", type "Antibodies"
| Hosts | Rabbit (8), Mouse (6) |
| Reactivities | Human (7), Rat (Rattus) (6), Mouse (Murine) (5), Cow (Bovine) (3), Hamster (3), Pig (Porcine) (2), Yeast (Pichia pastoris) (2), Dog (Canine) (1), Guinea Pig (1), Monkey (1), Sheep (Ovine) (1), Xenopus laevis (1), Yeast (1) |
| Applications | Western Blotting (WB) (14), Immunofluorescence (IF) (5), Immunoprecipitation (IP) (5), Immunohistochemistry (IHC) (4), ELISA (3), Flow Cytometry (FACS) (3), Immunocytochemistry (ICC) (3), Immunohistochemistry (Frozen Sections) (IHC (fro)) (2), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (2), ELISA (Detection) (1) |
| Epitopes | C-Term (1) |
