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Heat Shock 22kDa Protein 8 (HSPB8) antibody

Details for Product No. ABIN361851
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Antigen
Synonyms H11, HMN2, CMT2L, DHMN2, E2IG1, HMN2A, HSP22, H11K, Cryac, D5Ucla4, AU018630, AW413033, HSP20-like, Hsp22, MGC64408, fc09c11, wu:fc04b04, wu:fc09c11, zgc:64202
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(84), (24), (21), (13), (13), (12)
Host
Rabbit
(40), (38), (8)
Clonality
Polyclonal
Conjugate
Un-conjugated
(4), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF)
(72), (47), (36), (24), (10), (9), (8), (4), (4), (2), (1)
Pubmed 5 references available
Quantity 25 µL
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Availability Will be delivered in 3 to 4 Business Days
Catalog No. ABIN361851
167.20 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen Human Hsp22
Isotype IgG
Specificity Detects approx. 22 kDa.
Cross-Reactivity (Details) Does not cross-react with Hsp27 or alpha-crystallin.
Alternative Name Hsp22
Background Synonyms:
Alpha crystallin C chain, CMT2L, CRYAC, DHMN2, H11, Heat shock 22 kDa protein 8, HMN2, HSB8, HspB8
Hsp22 (HSPB8) is a 196 AA protein that is a member of the small heat shock protein super-family and the human protein is most closely related to Hsp27. Similar to most other sHSPs, Hsp22 is predominately transcribed in skeletal muscle and heart, as well as the placenta. Hsp22 is a monomeric protein which interacts with HSPB1. It displays temperature-dependent chaperone activity.In a two hybrid screen, HspB8 interacted preferentially with a triple aspartate form of Hsp27 which mimics Hsp27 phosphorylated at Ser15, Ser78, and Ser82, as compared to wild-type Hsp27. HSPB8 has two binding domains (N and C Terminal) that are specific for different binding partners, and has the ability to bind itself and other sHSPs. The chaperone-like activity is of great importance to the function of Hsp22 in various processes including proliferation, apoptosis and macro autophagy.Mutations in the HSPB8 gene are associated with the inherited peripheral neuropathies, autosomal dominant distal hereditary motor neuropathy type IIA (dSMA) and axonal Charcot-Marie-Tooth disease type 2L (CMT2L).
Gene ID 26353
NCBI Accession NP_055180.1
UniProt Q9UJY1
Research Area Neurology, Heat Shock Proteins
Application Notes Recommended Dilution: 1:1000 (WB)
Restrictions For Research Use only
Format Liquid
Storage -20 °C
Supplier Images
anti-Heat Shock 22kDa Protein 8 (HSPB8) antibody Hsp22, Mouse Spinal Cord
Background publications Benndorf, Sun, Gilmont et al.: "HSP22, a new member of the small heat shock protein superfamily, interacts with mimic of phosphorylated HSP27 ((3D)HSP27)." in: The Journal of biological chemistry, Vol. 276, Issue 29, pp. 26753-61, 2001 (PubMed).

Kappé, Verschuure, Philipsen et al.: "Characterization of two novel human small heat shock proteins: protein kinase-related HspB8 and testis-specific HspB9." in: Biochimica et biophysica acta, Vol. 1520, Issue 1, pp. 1-6, 2001 (PubMed).

Sun, Fontaine, Rest et al.: "Interaction of human HSP22 (HSPB8) with other small heat shock proteins." in: The Journal of biological chemistry, Vol. 279, Issue 4, pp. 2394-402, 2004 (PubMed).

Kim, Seit-Nebi, Gusev: "The problem of protein kinase activity of small heat shock protein Hsp22 (H11 or HspB8)." in: Biochemical and biophysical research communications, Vol. 325, Issue 3, pp. 649-52, 2004 (PubMed).

Wilhelmus, Boelens, Otte-Höller et al.: "Small heat shock protein HspB8: its distribution in Alzheimer's disease brains and its inhibition of amyloid-beta protein aggregation and cerebrovascular amyloid-beta toxicity." in: Acta neuropathologica, Vol. 111, Issue 2, pp. 139-49, 2006 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN361851
167.20 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
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