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BCL2L1 antibody (BCL2-Like 1) (AA 60-64)

Details for Product anti-BCL2L1 Antibody No. ABIN362597, Supplier: Login to see
Antigen
Alternatives
anti-Human BCL2L1 antibody for Immunohistochemistry (Paraffin-embedded Sections)
Epitope
AA 60-64
40
27
26
22
19
13
13
13
12
11
10
8
7
7
6
6
5
5
4
4
3
3
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
351
173
149
22
10
8
6
5
3
2
2
1
Host
Rabbit
267
118
4
3
Clonality
Polyclonal
Conjugate
This BCL2L1 antibody is un-conjugated
18
13
6
4
4
2
2
2
2
2
2
2
2
Application
Western Blotting (WB)
280
147
91
82
76
55
54
26
25
14
7
4
3
3
2
1
1
Supplier
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Immunogen Peptide sequence around AA 60-64 (A-D-S-P-A) derived from human BCL-XL . Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.
Isotype IgG
Specificity The antibody detects endogenous level of total BCL-XL protein.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Alternative Name BCL-XL (BCL2L1 Antibody Abstract)
Background Potent inhibitor of cell death. Isoform Bcl-X(L) anti-apoptotic activity is inhibited by association with SIVA isoform 1. Inhibits activation of caspases By similarity. Appears to regulate cell death by blocking the voltage-dependent anion channnel (VDAC) by binding to it and preventing the release of the caspase activator, cytochrome c, from the mitochondrial membrane. The Bcl-X(S) isoform promotes apoptosis.
Molecular Weight 30 kDa
NCBI Accession NP_612815
UniProt Q07817
Pathways Apoptosis
Application Notes Western blotting: 1:500-1:1000
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
Background publications Basu, Ramkumar, Tan et al.: "Reversal of acute cellular rejection after renal transplantation with Campath-1H." in: Transplantation proceedings, Vol. 37, Issue 2, pp. 923-6, 2005 (PubMed).

Yu, Zhang, Hwang et al.: "PUMA induces the rapid apoptosis of colorectal cancer cells." in: Molecular cell, Vol. 7, Issue 3, pp. 673-82, 2001 (PubMed).

Sattler, Liang, Nettesheim et al.: "Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis." in: Science (New York, N.Y.), Vol. 275, Issue 5302, pp. 983-6, 1997 (PubMed).

Muchmore, Sattler, Liang et al.: "X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death." in: Nature, Vol. 381, Issue 6580, pp. 335-41, 1996 (PubMed).

Cheng, Levine, Boise et al.: "Bax-independent inhibition of apoptosis by Bcl-XL." in: Nature, Vol. 379, Issue 6565, pp. 554-6, 1996 (PubMed).