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BCL2-Like 1 (BCL2L1) (AA 60-64) antibody

Details for Product No. ABIN362597
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Antigen
Synonyms
BCL-XL/S, BCL2L, BCLX, BCLXL, BCLXS, Bcl-X, PPP1R52, bcl-xL, bcl-xS, Bcl(X)L, Bcl-XL, Bcl-Xs, Bcl2l, BclX, bcl-x, Bclx, bcl-X, Bcl-xl, Bcl-xL, BCL-XL, bcl-XL, bcl-x(l), bclxl, xR11, BCL2L1, bcl-xl/s,  ... show more
BCL-XL/S, BCL2L, BCLX, BCLXL, BCLXS, Bcl-X, PPP1R52, bcl-xL, bcl-xS, Bcl(X)L, Bcl-XL, Bcl-Xs, Bcl2l, BclX, bcl-x, Bclx, bcl-X, Bcl-xl, Bcl-xL, BCL-XL, bcl-XL, bcl-x(l), bclxl, xR11, BCL2L1, bcl-xl/s, bcl-xs, bcl2l, bclx, bcl-xl, Bcl-xS show less
Epitope
AA 60-64
(31), (29), (20), (19), (9), (9), (8), (7), (5), (4), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(277), (157), (134), (40), (40), (39), (12), (4), (3), (2), (1), (1)
Host
Rabbit
(217), (83), (3), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(14), (8), (4), (4), (4), (4), (4), (4), (4), (4), (4), (3), (2), (1), (1)
Application
Western Blotting (WB)
(211), (98), (84), (69), (44), (40), (37), (35), (17), (15), (2), (2), (2), (1)
Pubmed 5 references available
Quantity 50 µL
Shipping to United States (Change)
Availability Will be delivered in 2 to 3 Business Days
Catalog No. ABIN362597
165.00 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen Peptide sequence around AA 60-64 (A-D-S-P-A) derived from human BCL-XL . Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.
Isotype IgG
Specificity The antibody detects endogenous level of total BCL-XL protein.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Alternative Name BCL-XL
Background Potent inhibitor of cell death. Isoform Bcl-X(L) anti-apoptotic activity is inhibited by association with SIVA isoform 1. Inhibits activation of caspases By similarity. Appears to regulate cell death by blocking the voltage-dependent anion channnel (VDAC) by binding to it and preventing the release of the caspase activator, cytochrome c, from the mitochondrial membrane. The Bcl-X(S) isoform promotes apoptosis.
Molecular Weight 30 kDa
NCBI Accession NP_612815
UniProt Q07817
Application Notes Western blotting: 1:500-1:1000
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
Background publications Cheng, Levine, Boise et al.: "Bax-independent inhibition of apoptosis by Bcl-XL." in: Nature, Vol. 379, Issue 6565, pp. 554-6, 1996 (PubMed).

Muchmore, Sattler, Liang et al.: "X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death." in: Nature, Vol. 381, Issue 6580, pp. 335-41, 1996 (PubMed).

Sattler, Liang, Nettesheim et al.: "Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis." in: Science (New York, N.Y.), Vol. 275, Issue 5302, pp. 983-6, 1997 (PubMed).

Yu, Zhang, Hwang et al.: "PUMA induces the rapid apoptosis of colorectal cancer cells." in: Molecular cell, Vol. 7, Issue 3, pp. 673-82, 2001 (PubMed).

Basu, Ramkumar, Tan et al.: "Reversal of acute cellular rejection after renal transplantation with Campath-1H." in: Transplantation proceedings, Vol. 37, Issue 2, pp. 923-6, 2005 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN362597
165.00 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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