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BCL2L1 antibody (BCL2-Like 1)

Details for Product anti-BCL2L1 Antibody No. ABIN371611, Supplier: Login to see
Antigen
  • bcl-XL
  • bcl-x
  • bcl-x(l)
  • bcl-xl/s
  • bcl-xs
  • bcl2l
  • bclx
  • bclxl
  • xR11
  • BCL2L1
  • Bcl-xS
  • BCL-XL/S
  • BCL2L
  • BCLX
  • BCLXL
  • BCLXS
  • Bcl-X
  • PPP1R52
  • bcl-xL
  • bcl-xS
  • Bcl(X)L
  • Bcl-XL
  • Bcl-Xs
  • Bcl2l
  • BclX
  • Bcl-xl
  • Bclx
  • bcl-X
  • BCL-XL
  • Bcl-xL
  • bcl-xl
Alternatives
anti-Human BCL2L1 antibody for Immunohistochemistry (Paraffin-embedded Sections)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
350
172
148
22
10
8
6
5
3
2
2
1
Host
Mouse
267
117
4
3
Clonality (Clone)
Monoclonal ()
Conjugate
This BCL2L1 antibody is un-conjugated
18
13
6
4
4
2
2
2
2
2
2
2
2
Application
Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunoprecipitation (IP), Western Blotting (WB)
279
147
91
82
76
54
53
26
25
13
7
4
3
3
2
1
1
Supplier
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Immunogen Recombinant Bcl-xS.
Clone 7B2-5
Isotype IgG3
Specificity This antibody recognizes Bcl-xL.
Characteristics Synonyms: Bcl2-L-1, BCL2L1, BCL2L, BCLX, Bcl-x, bcl-xL, bcl-xS, Bcl-2-like protein 1
Purification Purified
Alternative Name Bcl-2-Like 1 (BCL2L1 Antibody Abstract)
Background Apoptosis, or programmed cell death, is a well-documented phenomenon in many cellular systems. (Ref.1) It plays a key role in tissue and organ development as well as in adult tissues during cell turnover. Apoptosis can be induced by a variety of internal and external stimuli including growth factor deprivation, cytokine treatment, antigen-receptor engagement, cell-cell interactions, irradiation and glucocorticoid treatment. (Ref.2) Bcl-2 and one of its homologues, Bcl-xL, protect cells from apoptosis (Ref.3,4) while other homologues of Bcl-2 such as Bax, Bad and Bak have been shown to enhance apoptosis. (Ref.5-8) Bcl-xL has been shown to block apoptosis which is induced by a variety of stimuli and, under certain conditions, offers greater protection against apoptosis than Bcl-2. (Ref.9-13) In contrast, Bad and Bax inhibit the protective functions of Bcl-xL and Bcl-2, respectively. Although heterodimerization between Bcl-xL/Bad and Bcl-2/Bax was originally thought to be essential for the differential anti-apoptotic activity of Bcl-xL and Bcl-2. (Ref.5,14) Other results suggest that the formation of heterodimers may not be necessary for this death-repressing activity. (Ref.15,16)Synonyms: BCL2L, BCL2L1, BCLX, Bcl-2-like protein 1, Bcl-x, Bcl2-L-1, bcl-xL, bcl-xS
UniProt Q07817
Research Area Cancer
Pathways Apoptosis
Application Notes Flow Cytometry: < / = 3 μg/10^6 cells. Western Blot: < / = 0.5 μg/mL. Immunohistochemistry on Frozen Sections. Immunoprecipitation.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0.1 mg/mL
Buffer 100 mM Borate buffered saline, pH 8.0. No preservatives or amine-containing buffer salts added.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Expiry Date 12 months
Supplier Images
Flow Cytometry (FACS) image for anti-BCL2L1 antibody (BCL2-Like 1) (ABIN371611) anti-BCL2-Like 1 (BCL2L1) antibody
Background publications Gottschalk, Boise, Oltvai et al.: "The ability of Bcl-x(L) and Bcl-2 to prevent apoptosis can be differentially regulated." in: Cell death and differentiation, Vol. 3, Issue 1, pp. 113-8, 2006 (PubMed).

Nuñez, Clarke: "The Bcl-2 family of proteins: regulators of cell death and survival." in: Trends in cell biology, Vol. 4, Issue 11, pp. 399-403, 2004 (PubMed).

Cheng, Levine, Boise et al.: "Bax-independent inhibition of apoptosis by Bcl-XL." in: Nature, Vol. 379, Issue 6565, pp. 554-6, 1996 (PubMed).

Oltvai, Milliman, Korsmeyer: "Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death." in: Cell, Vol. 74, Issue 4, pp. 609-19, 1993 (PubMed).

Boise, González-García, Postema et al.: "bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death." in: Cell, Vol. 74, Issue 4, pp. 597-608, 1993 (PubMed).

Yin, Oltvai, Korsmeyer: "BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax." in: Nature, Vol. 369, Issue 6478, pp. 321-3, 1994 (PubMed).

Dole, Jasty, Cooper et al.: "Bcl-xL is expressed in neuroblastoma cells and modulates chemotherapy-induced apoptosis." in: Cancer research, Vol. 55, Issue 12, pp. 2576-82, 1995 (PubMed).

González-García, García, Ding et al.: "bcl-x is expressed in embryonic and postnatal neural tissues and functions to prevent neuronal cell death." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 92, Issue 10, pp. 4304-8, 1995 (PubMed).

Shimizu, Eguchi, Kosaka et al.: "Prevention of hypoxia-induced cell death by Bcl-2 and Bcl-xL." in: Nature, Vol. 374, Issue 6525, pp. 811-3, 1995 (PubMed).

Kiefer, Brauer, Powers et al.: "Modulation of apoptosis by the widely distributed Bcl-2 homologue Bak." in: Nature, Vol. 374, Issue 6524, pp. 736-9, 1995 (PubMed).

Chittenden, Harrington, OConnor et al.: "Induction of apoptosis by the Bcl-2 homologue Bak." in: Nature, Vol. 374, Issue 6524, pp. 733-6, 1995 (PubMed).

Farrow, White, Martinou et al.: "Cloning of a bcl-2 homologue by interaction with adenovirus E1B 19K." in: Nature, Vol. 374, Issue 6524, pp. 731-3, 1995 (PubMed).

Cory: "Regulation of lymphocyte survival by the bcl-2 gene family." in: Annual review of immunology, Vol. 13, pp. 513-43, 1995 (PubMed).

Gottschalk, Boise, Thompson et al.: "Identification of immunosuppressant-induced apoptosis in a murine B-cell line and its prevention by bcl-x but not bcl-2." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 91, Issue 15, pp. 7350-4, 1994 (PubMed).

Cohen: "Programmed cell death in the immune system." in: Advances in immunology, Vol. 50, pp. 55-85, 1991 (PubMed).