BAIAP2 antibody (C-Term, Isoform 3)

Catalog No. ABIN374111

The Goat Polyclonal anti-BAIAP2 antibody is suitable to detect BAIAP2 in samples from Human, Dog and Cow. It has been validated for WB.

Quick Overview for BAIAP2 antibody (C-Term, Isoform 3) (ABIN374111)

Target: BAIAP2 (BAI1-Associated Protein 2 (BAIAP2))

Reactivity: Human, Dog, Cow

Host: Goat

Clonality: Polyclonal

Conjugate: This BAIAP2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-BAIAP2 Antibody

Binding Specificity: C-Term, Isoform 3

Sequence: C-SMSSADVEVA RF

Specificity: This antibody will recognise only one of three reported isoforms (NP_006331.1) (Isofom 3).

Cross-Reactivity (Details): Species reactivity (expected):Canine (Dog), Bovine.
Species reactivity (tested):Human.

Purification: Ammonium Sulphate precipitation followed by antigen Affinity Chromatography using the immunizing peptide

Immunogen: Peptide from the C-Terminus of the protein sequence according to NP_006331.1. Genename: BAIAP2

Application Details

Application Notes: Peptide ELISA: Limit dilution 1: 16000. Western blot: 1-3 μg/mL. Approx 55 kDa band observed in Human Brain (Cerebellum andFrontal Cortex) lysates (calculated MW of 57.5 kDa according to NP_006331.1).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Tris saline, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C.

Target Details for BAIAP2

Target: BAIAP2 (BAI1-Associated Protein 2 (BAIAP2))

Alternative Name: BAIAP2

Background: BAIAP2, a target of p53, has been identified as a brain-specific angiogenesis inhibitor (BAI1)-binding protein. This interaction at the cytoplasmic membrane is crucial to the function of this protein, which may be involved in neuronal growth-cone guidance. This protein functions as an insulin receptor tyrosine kinase substrate and suggests a role for insulin in the central nervous system. This protein has also been identified as interacting with the dentatorubral-pallidoluysian atrophy gene, which is associated with an autosomal dominant neurodegenerative disease. It also associates with a downstream effector of Rho small G proteins, which is associated with the formation of stress fibers and cytokinesis.Synonyms: BAI-associated protein 2, BAI1-associated protein 2, BAP2, Brain-specific angiogenesis inhibitor 1-associated protein 2, FLAF3, Fas ligand-associated factor 3, IRS-58, IRSp53, IRSp53/58, Insulin receptor substrate p53, Insulin receptor substrate p53/p58, Insulin receptor substrate protein of 53 kDa

Gene ID: 10458

NCBI Accession: NP_006331

UniProt: Q9UQB8