Apolipoprotein E (APOE) (C-Term) antibody

Details for Product No. ABIN374539
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Antigen
Synonyms ad2, apoprotein, im:7036787, wu:fb69a05, zgc:110064, apoe, AI255918, AD2, LDLCQ5, LPG, APOEA, Apo-E
Epitope
C-Term
(20), (6), (5), (4), (3), (2), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(185), (49), (33), (5), (4), (1), (1)
Host
Goat
(113), (64), (47)
Clonality
Polyclonal
Conjugate
Un-conjugated
(14), (9), (4), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1)
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Paraffin-embedded Sections) (IHC (frpe)), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(160), (114), (49), (44), (20), (19), (19), (15), (10), (10), (10), (8), (7), (7), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Pubmed 1 reference available
Quantity 0.1 mg
Shipping to United States (Change)
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Catalog No. ABIN374539
357.50 $
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Immunogen Peptide with sequence from the C Terminus of the protein sequence according to NP_000032.1. Genename: APOE
Sequence C-VGTSAAPVPS DNH
Specificity This antibody recognizes Apolipoprotein E (C-term).
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide
Alternative Name Apolipoprotein E (Apo E)
Background Apolipoprotein E is essential for the normal catabolism of triglyceride rich lipoprotein constituents. The apolipoprotein E gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in Apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. Mutations in the APOE gene confer susceptibility to Alzheimer's disease by affecting amyloid-beta deposition.Synonyms: Apo-E, ApoE
Gene ID 348, 9606
UniProt P02649
Research Area Metabolism
Application Notes Peptide ELISA: 1/32000. Western blot: 0.1 - 0.3 μg/mL. Immunohistochemistry on paraffin sections: 2 - 4 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0.5 mg/mL
Buffer Tris saline, pH ~7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
anti-Apolipoprotein E (APOE) (C-Term) antibody anti-Apolipoprotein E (APOE) (C-Term) antibody
anti-Apolipoprotein E (APOE) (C-Term) antibody (2) anti-Apolipoprotein E (APOE) (C-Term) antibody (Image 2)
Background publications Dodart, Marr, Koistinaho et al.: "Gene delivery of human apolipoprotein E alters brain Abeta burden in a mouse model of Alzheimer's disease." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, Issue 4, pp. 1211-6, 2005 (PubMed).

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