LIM Domain Binding 3 (LDB3) antibody

Antigen: LIM Domain Binding 3 (LDB3)

Synonyms: ZASP, CYPHER, ORACLE, PDLIM6, ldb3z1, ldb3z4, FLJ35865, KIAA0613, KIAA01613, AW742271, MGC118603, ldb3l, zgc:55814, wu:fi31d08, ldb3, MGC52706, MGC75668, LDB3, RGD1564875

Clonality: Polyclonal

Host: Goat

Reactivity: Dog (Canine)

Application: Western Blotting (WB)

Catalog no.: ABIN374603

Additional Information

Characteristics: Synonyms: KIAA0613, ZASP, LIM domain-binding protein 3

Alternative name: LDB3

Gene ID: 11155

Swiss-Prot: O75112

Immunogen: Peptide with sequence C-KSQNKPEDEADE, from the internal region of the protein sequence

Cross-Reactivity: Dog (Canine), Human, Mouse (Murine), Rat (Rattus)

Description: LDB3 (LIM domain-binding protein 3) may function as an adapter in striated muscle tocouple protein kinase C-mediated signaling via its LIM domains to the cytoskeleton. Itinteractes with various PKC isoforms and with the C-terminal region of ACTN2 via its LIMand PDZ domains respectively. It also interacts with MYOZ1, MYOZ2 and MYOZ3. 6 isoformsare produced by alternative splicing. Defects in LDB3 are a cause of dilatedcardiomyopathy 1A, a disorder characterized by cardiac dilation and reduced systolicfunction, as well as ZASP-related myofibrillar myopathy, an autosomal dominant myopathythat is characterized by distal muscle weakness with signs of cardiomyopathy andneuropathy.

Specificity: This antibody reacts to LDB3. Species Reactivity: Tested: Human. Expected from sequence similarity: Mouse, Rat, Canine, Porcine.

Application Details

Application Notes: Peptide ELISA: 1/2000. Western Blot: 0.01 - 0.03 µg/ml. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.

Concentration: 0,5 mg/ml

Purification: Aff - Purified

Buffer: Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin

Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Research Area: Signaling

Restrictions: For Research Use only