Adenosine A2b Receptor antibody (C-Term)

Catalog No. ABIN374607

Product Details anti-Adenosine A2b Receptor Antibody

Target: Adenosine A2b Receptor (ADORA2B)

Binding Specificity: C-Term

Reactivity: Human

Host: Goat

Clonality: Polyclonal

Conjugate: This Adenosine A2b Receptor antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Sequence: CQADVKSGNG Q

Specificity: This anitbody recognizes Adenosine receptor A2b.

Purification: Affinity chromatography

Immunogen: Peptide with sequence from the C Terminus of the protein sequence (NP_000667.1). Genename: ADORA2B

Application Details

Application Notes: Peptide ELISA: 1/4000. Western Blot. Immunohistochemistry on paraffin sections: 3 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Tris saline, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for Adenosine A2b Receptor

Target: Adenosine A2b Receptor (ADORA2B)

Alternative Name: Adenosine Receptor A2b (ADORA2B Products)

Synonyms: si:dkey-13b16.1 antibody, ADORA2B antibody, LOC606745 antibody, LOC100220469 antibody, ADORA2 antibody, A2BAR antibody, A2BR antibody, A2b antibody, AA2BR antibody, AI480866 antibody, AI605384 antibody, adenosine A2b receptor antibody, adenosine A2B receptor antibody, adora2b antibody, ADORA2B antibody, Adora2b antibody

Background: Adenosine is involved in a variety of processes, including the synthesis of urea, the anti-inflammatory response, and the inhibition of protein synthesis. The adenosine receptors, including adenosine A1-R, adenosine A2A-R, adenosine A2B-R, and adenosine A3-R, are integral membrane proteins that are members of the G protein-coupled receptor family. The A1-R protein mediates ureagenesis in a partially calcium-dependent manner. Adenosine is known to mediate coronary vasodilation via the A2A-R receptor. Collagen synthasis and total protein synthesis are inhibited in certain cells by adenosine, acting via the A2B receptors. Activation of the A3-R receptor inhibits the induction of the cytokine TNFα and blocks the endotoxin CD14 receptor signal transduction pathway.Synonyms: ADORA2B

Gene ID: 136, 9606

UniProt: P29275

Pathways: cAMP Metabolic Process, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process