LPIN3 antibody (Internal Region)

Catalog No. ABIN374744

The Goat Polyclonal anti-LPIN3 antibody is suitable to detect LPIN3 in samples from Human. It has been validated for IHC (p).

Quick Overview for LPIN3 antibody (Internal Region) (ABIN374744)

Target: LPIN3 (Lipin 3 (LPIN3))

Reactivity: Human

Host: Goat

Clonality: Polyclonal

Conjugate: This LPIN3 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-LPIN3 Antibody

Binding Specificity: Internal Region

Specificity: This antibody reacts to Lipin 3.

Purification: Affinity chromatography

Immunogen: Peptide with sequence C-KPKQKEDAVATD, from the internal region of the protein sequence

Application Details

Application Notes: Peptide ELISA: 1/64000. Western Blot: 0.1 μg/mL. Immunohistochemistry on paraffin sections: 2 - 3 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for LPIN3

Target: LPIN3 (Lipin 3 (LPIN3))

Alternative Name: Lipin-3

Background: Humans lipodystrophy is characterized by loss of body fat, fatty liver, hypertriglyceridemia, and insulin resistance. Mice carrying mutations in the fatty liver dystrophy (fld) gene have similar phenotypes. Through positional cloning, the mouse gene responsible for fatty liver dystrophy was isolated and designated Lpin1. The nuclear protein encoded by Lpin1 was named lipin. Lpin1 mRNA was expressed at high levels in adipose tissue and was induced during differentiation of preadipocytes. These results indicated that lipin is required for normal adipose tissue development and provided a candidate gene for human lipodystrophy. Through database searches, mouse and human EST and genomic sequences with similarities to Lpin1 were identified. These included two related mouse genes (Lpin2 and Lpin3) and three human homologs (LPIN1, LPIN2, and LPIN3).Synonyms: LIPN3L, LPIN3, Lipin-3-like, Lipin3

Gene ID: 64900, 9606

UniProt: Q9BQK8