Galactosamine (N-Acetyl)-6-Sulfate Sulfatase (GALNS) antibody

Antigen: Galactosamine (N-Acetyl)-6-Sulfate Sulfatase (GALNS)

Synonyms: GAS, MPS4A, FLJ17434, FLJ42844, FLJ98217, GALNAC6S, FLJ00319, mFLJ00319, Galns, GALNS

Clonality: Polyclonal

Host: Goat

Reactivity: Human

Application: Western Blotting (WB)

Catalog no.: ABIN374878

Additional Information

Characteristics: Synonyms: N-acetylgalactosamine-6-sulfatase, EC=3.1.6.4, N-acetylgalactosamine-6-sulfate sulfatase,Galactose-6-sulfate sulfatase, GalNAc6S sulfatase, Chondroitinsulfatase, Chondroitinase

Alternative name: GALNS

Swiss-Prot: P34059

Immunogen: Peptide from the internal region of the protein sequence according to NP_000503. 1Genename: GALNSAA Sequence: C-TTHNLEDHTKLP

Cross-Reactivity: Human

Description: GALNS (N-acetylgalactosamine-6-sulfatase) is a lysosomal exohydrolase which catalyzesthe hydrolysis of the 6-sulfate groups of the N-acetyl-D-galactosamine 6-sulfate units ofchondroitin sulfate and of the D-galactose 6-sulfate units of keratan sulfate. Deficienciesof this enzyme lead to Morquio A syndrome, a lysosomal storage disorder.

Specificity: This antibody detects GALNS. Species Reactivity: Tested: Human

Application Details

Application Notes: Peptide ELISA: limit dilution 1: 64000. Western blot: 0.01-0.03µg/ml. Approx 60kDa band observed in Human Bone Marrow andPlacenta lysates (calculated MW of 58.0kDa according to NP_000503.1). Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.

Concentration: 0.5 mg/ml

Purification: Aff - Purified

Buffer: Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin

Storage: Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer. Avoidrepeated freezing and thawing. Shelf life: one year from despatch.

Research Area: Proteolysis / Ubiquitin, Extracellular Matrix, Organelles

Restrictions: For Research Use only