MC2R antibody (N-Term)

Catalog No. ABIN374914

This Goat Polyclonal antibody specifically detects MC2R in WB. It exhibits reactivity toward Human.

Quick Overview for MC2R antibody (N-Term) (ABIN374914)

Target: MC2R (Melanocortin 2 Receptor (Adrenocorticotropic Hormone) (MC2R))

Reactivity: Human

Host: Goat

Clonality: Polyclonal

Conjugate: This MC2R antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-MC2R Antibody

Binding Specificity: N-Term

Specificity: This antibody reacts to MC2R / ACTHR.

Purification: Affinity chromatography

Immunogen: Peptide with sequence ENINNTARNNSDC, from the N Terminus of the protein sequence

Application Details

Application Notes: Peptide ELISA: 1/32000. Western Blot: 1 - 3 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 0,5 mg/mL

Buffer: Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for MC2R

Target: MC2R (Melanocortin 2 Receptor (Adrenocorticotropic Hormone) (MC2R))

Alternative Name: MC2-R

Background: MC2 receptor is the second member of the five known melanocortin receptors (MCRs) belonging to the rhodopsin-like family of G protein-coupled receptors (GPCRs). These five MCRs form a unique family of GPCRs, marked by their unusually short coding sequence and the absence of highly conserved amino acid residues or motifs common to most GPCRs. All MCRs signal through the cyclic adenosine 3', 5'-monophosphate (cAMP) pathway. MC2 receptor is the smallest MCR and the smallest known GPCR (297 amino acids). It exclusively binds the adrenocorticotrophic hormone (ACTH) and this binding plays a pivotal role in homeostasis, metabolism, and stress response. In contrast, the other four MCRs are activated by both ACTH and melanocyte-stimulating hormones (MSHs and mainly alpha-MSH). The MC2 receptor is predominantly expressed in the adrenal gland but is also found in the murine adipocyte. Mutations in MC2R can result in familial glucocorticoid deficiency.Synonyms: ACTH receptor, ACTH-R, ACTHR, Adrenocorticotropic hormone receptor, Adrenocorticotropin receptor, MC2R

Gene ID: 4158, 9606

UniProt: Q01718

Pathways: cAMP Metabolic Process