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Potassium Inwardly-Rectifying Channel, Subfamily J, Member 1 (KCNJ1) (Internal Region) antibody

Details for Product No. ABIN375086
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Antigen
Synonyms kcnj1, MGC68935, KIR1.1, ROMK, ROMK1, Kcnj, Kir1.1, Romk2, kir1.1, romk1, wu:fl37c05, zgc:63534
Epitope
Internal Region
(16), (7), (7), (3), (3), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(41), (23), (23), (13), (1), (1)
Host
Goat
(38), (3), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(24), (22), (10), (8), (8), (3), (1)
Pubmed 1 reference available
Quantity 0.1 mg
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Catalog No. ABIN375086
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Immunogen Peptide with sequence from the internal region of the protein sequence according to NP_000211.1, NP_722448.1. Genename: KCNJ1
Sequence C-DQININFVVDAGNEN
Specificity This antibody is expected to recognize reported isoforms (NP_722449.2 and NP_000211) of KCNJ1. Species Reactivity: Tested: Human. Expected from sequence similarity: Mouse, Rat.
Purification Affinity Chromatography.
Alternative Name KCNJ1
Background Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. KCNJ1 is an integral membrane protein and inward rectifier type potassium channel. It is activated by internal ATP and probably plays an important role in potassium homeostasis. The KCNJ1 channel is blocked by external barium. WNK1 has been shown to inhibit KCNJ1 by enhancing its endocytosis. Mutations in this gene have been associated with antenatal Bartter syndrome, which is characterized by salt wasting, hypokalemic alkalosis, hypercalciuria, and low blood pressure.
Alternate names: ATP-regulated potassium channel ROM-K, ATP-sensitive inward rectifier potassium channel 1, KCNJ1, Kir1.1, Potassium channel, ROMK1, inwardly rectifying subfamily J member 1
Gene ID 3758
NCBI Accession NP_000211.1
UniProt P48048
Research Area Signaling, Metabolism
Application Notes Peptide ELISA: 1/8000. Western Blot: 1 - 3 µg/ml. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer Tris buffered saline, pH~7.3 containing 0.02% Sodium Azide as preservative and 0.5% BSA as stabilizer.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Supplier Images
anti-Potassium Inwardly-Rectifying Channel, Subfamily J, Member 1 (KCNJ1) (Internal Region) antibody anti-Potassium Inwardly-Rectifying Channel, Subfamily J, Member 1 (KCNJ1) (Internal Region) antibody
Background publications Ji, Foo, ORoak et al.: "Rare independent mutations in renal salt handling genes contribute to blood pressure variation." in: Nature genetics, Vol. 40, Issue 5, pp. 592-9, 2008 (PubMed).

Validation Images
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