KCNJ1 antibody (Middle Region)

Catalog No. ABIN2776290

Product Details anti-KCNJ1 Antibody

Target: KCNJ1 (Potassium Inwardly-Rectifying Channel, Subfamily J, Member 1 (KCNJ1))

Binding Specificity: Middle Region

Reactivity: Human, Rat, Mouse, Horse, Cow, Guinea Pig, Rabbit, Dog, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KCNJ1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: LRKSLLIGSH IYGKLLKTTV TPEGETIILD QININFVVDA GNENLFFISP

Predicted Reactivity: Cow: 86%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 100%, Zebrafish: 86%

Characteristics: This is a rabbit polyclonal antibody against KCNJ1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human KCNJ1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 391 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-KCNJ1 antibody (ABIN2776290)

Tobin, Tomaszewski, Braund, Hajat, Raleigh, Palmer, Caulfield, Burton, Samani: "Common variants in genes underlying monogenic hypertension and hypotension and blood pressure in the general population." in: Hypertension, Vol. 51, Issue 6, pp. 1658-64, (2008) (PubMed).

Target Details for KCNJ1

Target: KCNJ1 (Potassium Inwardly-Rectifying Channel, Subfamily J, Member 1 (KCNJ1))

Alternative Name: KCNJ1 (KCNJ1 Products)

Synonyms: KIR1.1 antibody, ROMK antibody, ROMK1 antibody, kir1.1 antibody, romk1 antibody, Kcnj antibody, Kir1.1 antibody, Romk2 antibody, kcnj1 antibody, wu:fl37c05 antibody, zgc:63534 antibody, potassium voltage-gated channel subfamily J member 1 antibody, potassium voltage-gated channel subfamily J member 1 L homeolog antibody, potassium inwardly-rectifying channel, subfamily J, member 1 antibody, potassium inwardly-rectifying channel, subfamily J, member 1a, tandem duplicate 1 antibody, KCNJ1 antibody, kcnj1.L antibody, kcnj1 antibody, Kcnj1 antibody, kcnj1a.1 antibody

Background: KCNJ1 has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Mutations in this gene have been associated with antenatal Bartter syndrome, which is characterized by salt wasting, hypokalemic alkalosis, hypercalciuria, and low blood pressure. Multiple transcript variants encoding different isoforms have been found for KCNJ1.Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. It is activated by internal ATP and probably plays an important role in potassium homeostasis.Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. It is activated by internal ATP and probably plays an important role in potassium homeostasis. The encoded protein has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Mutations in this gene have been associated with antenatal Bartter syndrome, which is characterized by salt wasting, hypokalemic alkalosis, hypercalciuria, and low blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: KIR1.1, ROMK, ROMK1
Protein Interaction Partner: SH3RF1, UBC, SLC9A3R2, SLC9A3R1, SGK1, GOLGA3, PRKCD, IL16, CFTR,
Protein Size: 391

Molecular Weight: 45 kDa

Gene ID: 3758

NCBI Accession: NM_000220, NP_000211

UniProt: P48048