FAIM antibody (Internal Region)

Catalog No. ABIN375120

The Goat Polyclonal anti-FAIM antibody (ABIN375120) specifically detects FAIM in WB and IHC (p). The antibody is reactive with Human, Mouse, Rat and Dog samples.

Quick Overview for FAIM antibody (Internal Region) (ABIN375120)

Target: FAIM (Fas Apoptotic Inhibitory Molecule (FAIM))

Reactivity: Human, Mouse, Rat, Dog

Host: Goat

Clonality: Polyclonal

Conjugate: This FAIM antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-FAIM Antibody

Binding Specificity: Internal Region

Specificity: This antibody reacts to all reported isoforms of FAIM1.

Cross-Reactivity (Details): Species reactivity (expected):Mouse, Rat, Canine.
Species reactivity (tested):Human.

Purification: Affinity chromatography

Immunogen: Peptide with sequence C-KKYMEDRSKTTN, from the internal region of the protein sequence

Application Details

Application Notes: Peptide ELISA: 1/32000. Western Blot: 0.5 - 1 μg/mL. Immunohistochemistry on paraffin sections: 2 - 3 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 0,5 mg/mL

Buffer: Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for FAIM

Target: FAIM (Fas Apoptotic Inhibitory Molecule (FAIM))

Alternative Name: FAIM

Background: FAIM1 (or Fas Apoptotic Inhibitory Molecule 1) is a recently discovered negative regulator of apoptosis. FAIM1 has no significant regions of homology to other gene products that modulate Fas killing. It plays a role as an inducible effector molecule that mediates Fas resistance produced by surface Ig engagement in B cells. Overexpression of FAIM1 diminishes sensitivity to Fas mediated apoptosis of B and non B cell lines. FAIM1 is highly evolutionarily conserved and is widely expressed in murine tissues, suggesting that FAIM1 plays an important role in cellular physiology.Synonyms: FAIM-1, FAIM1, Fas Apoptotic Inhibitory Molecule 1

Gene ID: 55179, 9606

UniProt: Q9NVQ4