Biglycan antibody (C-Term)
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- Target See all Biglycan (BGN) Antibodies
- Biglycan (BGN)
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Binding Specificity
- C-Term
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Reactivity
- Human, Rat, Mouse, Dog
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Host
- Goat
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Clonality
- Polyclonal
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Conjugate
- This Biglycan antibody is un-conjugated
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Application
- Western Blotting (WB), Enzyme Immunoassay (EIA)
- Sequence
- C-DRLAIQFGNY KK
- Specificity
- This antibody recognizes Biglycan Preproprotein.
- Cross-Reactivity (Details)
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Species reactivity (expected):Mouse, Canine.
Species reactivity (tested):Human, Rat. - Purification
- Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide
- Immunogen
- Synthetic peptide from the C-Terminus of Human Biglycan (NP_001702.1) Genename: BGN
- Top Product
- Discover our top product BGN Primary Antibody
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- Application Notes
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Peptide ELISA: 1/8000. Western Blot: 0.1 - 0.3 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
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- Concentration
- 0.5 mg/mL
- Buffer
- Tris saline, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA
- Preservative
- Sodium azide
- Precaution of Use
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freezing and thawing.
- Storage
- 4 °C/-20 °C
- Storage Comment
- Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- Target
- Biglycan (BGN)
- Alternative Name
- Biglycan (BGN Products)
- Synonyms
- DSPG1 antibody, PG-S1 antibody, PGI antibody, SLRR1A antibody, BG antibody, BSPG1 antibody, bgn antibody, zgc:91989 antibody, dspg1 antibody, pg-s1 antibody, slrr1a antibody, xbgn antibody, BGN antibody, zgc:77123 antibody, DKFZp468I2427 antibody, biglycan antibody, biglycan L homeolog antibody, biglycan a antibody, biglycan S homeolog antibody, biglycan b antibody, BGN antibody, Bgn antibody, bgn.L antibody, bgna antibody, bgn.S antibody, bgn antibody, bgnb antibody
- Background
- Biglycan is an extracellular matrix proteoglycan that is closely related in structure to decorin and fibromodulin. Biglycan and decorin are thought to be the result of a gene duplication. Biglycan is expressed in secondary myotubes during fetal muscle formation. In adult muscle it is located in the endomysium and neuromuscular junctions, where it connects to the dystrophin-associated proteins through binding to a-dystroglycan. In developing newborn mice biglycan expression is initially high and then decreases during skeletal muscle differentiation and maturation. Biglycan may also have a role in the fibrotic process since it is overexpressed in atherosclerotic lesions and has been shown to cause an increase in thymidine incorporation and migration of vascular smooth muscle cells.Synonyms: BGN, Bone/cartilage proteoglycan I, PG-S1, PGS1, SLRR1A, Small Leucine-rich Protein 1A
- Molecular Weight
- 41.7 kDa (Human NP_001702.1 and Rat NP_058783.1)
- Gene ID
- 633
- NCBI Accession
- NP_001702
- UniProt
- P21810
- Pathways
- Glycosaminoglycan Metabolic Process
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