|+1 404 474 4654|
|+1 888 205 9894 (TF)|
TAU (C-Term) antibody
Alternatives Western Blotting (WB), Immunohistochemistry (IHC), ELISA
|4 references available|
|Quantity||400 µL (0.25 mg/ml)|
|Price||280.50 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Immunogen||This TAU antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 685~714 amino acids from the C-terminal region of human TAU.|
|Description||Other names: Microtubule-associated protein tau, Neurofibrillary tangle protein, Paired helical filament-tau, PHF-tau, MAPT, MAPTL, MTBT1, TAU|
|Characteristics||Purified Rabbit Polyclonal Antibody (Pab)|
|Specificity||This TAU antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 685~714 amino acids from the C-terminal region of human TAU.|
|Molecular Weight||78746 DA|
Background: The microtubule-associated protein tau (MAPT) gene transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations result in several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.
|Application Notes||The suggested dilution will be: ELISA~~1:1,000 Western blotting~~1:50~100 Immunohistochemistry~~1:50~100|
|Buffer||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles|
|Research Area||Stem Cells, Cell Structure, Neurology|
|Restrictions||For Research Use only|
Kraemer, Zhang, Leverenz et al.: "Neurodegeneration and defective neurotransmission in a Caenorhabditis elegans model of tauopathy." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 17, pp. 9980-5, 2003 (PubMed).
Gamblin, Chen, Zambrano et al.: "Caspase cleavage of tau: linking amyloid and neurofibrillary tangles in Alzheimer's disease." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 17, pp. 10032-7, 2003 (PubMed).
Horiguchi, Uryu, Giasson et al.: "Nitration of tau protein is linked to neurodegeneration in tauopathies." in: The American journal of pathology, Vol. 163, Issue 3, pp. 1021-31, 2003 (PubMed).
Yoshiyama, Zhang, Bruce et al.: "Reduction of detyrosinated microtubules and Golgi fragmentation are linked to tau-induced degeneration in astrocytes." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 23, Issue 33, pp. 10662-71, 2003 (PubMed).