ABL2 (Center) antibody

Details for Product No. ABIN389506
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Antigen
Synonyms ABLL, ARG, AA536808, Abll, Arg
Epitope
Center
(7), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(55), (24), (15), (12), (12)
Host
Rabbit
(31), (26)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Dot Blot (DB), Immunohistochemistry (IHC)
(48), (35), (20), (10), (10), (9), (4), (3), (2), (2), (1), (1), (1)
Pubmed 4 references available
Catalog no. ABIN389506
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Immunogen This ABL Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y412 of human ABL.
Clone RB7532
Isotype Ig
Specificity This Phospho-ABL-Y412 Antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the central region of human ABL.
Predicted Reactivity Mouse (Murine)
Purification This antibody is purified through a protein G column, followed by dialysis against PBS.
Background ABL2 is a cytoplasmic tyrosine kinase which is closely related to but distinct from ABL1. The similarity of the proteins includes the tyrosine kinase domains and extends amino-terminal to include the SH2 and SH3 domains. ABL2 is expressed in both normal and tumor cells.
Synonyms: Tyrosine-protein kinase ABL2, Abelson murine leukemia viral oncogene homolog 2, Tyrosine kinase ARG, ABL2, ABLL, ARG,
Molecular Weight 128343 DA
Gene ID 27
UniProt P42684
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cancer, Cell Cycle, Cell Structure
Application Notes WB = 1:1000, DB = 1:500, IHC = 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 0.34 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-ABL2 (Center) antibody Western blot analysis of anti-ABL2 Pab (ABIN389506) in A2058 cell line lysate (35 µg/lane). ABL2(arrow) was detected using the purified polyclonal antibody (1:14 dilution).
anti-ABL2 (Center) antibody (2) Dot blot analysis of ABL-Y412 Phospho-specific Pab (ABIN389506) on nitrocellulose membrane. 50 ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5 µg/mL.
anti-ABL2 (Center) antibody (3) Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma
Background publications Kruh, Perego, Miki et al.: "The complete coding sequence of arg defines the Abelson subfamily of cytoplasmic tyrosine kinases." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 87, Issue 15, pp. 5802-6, 1990 (PubMed).

Kruh, King, Kraus et al.: "A novel human gene closely related to the abl proto-oncogene." in: Science (New York, N.Y.), Vol. 234, Issue 4783, pp. 1545-8, 1987 (PubMed).

Cao, Leng, Kufe: "Catalase activity is regulated by c-Abl and Arg in the oxidative stress response." in: The Journal of biological chemistry, Vol. 278, Issue 32, pp. 29667-75, 2003 (PubMed).

Cao, Leng, Liu et al.: "Catalase is regulated by ubiquitination and proteosomal degradation. Role of the c-Abl and Arg tyrosine kinases." in: Biochemistry, Vol. 42, Issue 35, pp. 10348-53, 2003 (PubMed).

Hosts (31), (26)
Reactivities (55), (24), (15), (12), (12)
Applications (48), (35), (20), (10), (10), (9), (4), (3), (2), (2), (1), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (7), (2), (1), (1), (1), (1), (1), (1), (1), (1)
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