|+1 404 474 4654|
|+1 888 205 9894 (TF)|
ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 7 (ABCB7) (C-Term) antibody
|Synonyms||ABC7, ASAT, Atm1p, EST140535, Abc7, AA517758, AU019072, CG7955, dABCB7, DmelCG7955, ABCB7, GB11034, fc20c02, wu:fc20c02|
Alternatives Western Blotting (WB), Immunohistochemistry (IHC), ELISA
|5 references available|
|Quantity||0.1 mg (0.25 mg/ml)|
|Price||280.50 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Immunogen||This ABCB7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 723~752 amino acids from the C-terminal region of human ABCB7.|
|Characteristics||Purified Rabbit Polyclonal Antibody (Pab)|
|Specificity||This ABCB7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 723~752 amino acids from the C-terminal region of human ABCB7.|
|Molecular Weight||82641 DA|
Background: The membrane-associated protein ABCB7 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a half-transporter involved in the transport of heme from the mitochondria to the cytosol. With iron/sulfur cluster precursors as its substrates, this protein may play a role in metal homeostasis. Mutations in this gene have been implicated in X-linked sideroblastic anemia with ataxia.
|Application Notes||The suggested dilution is: ELISA~~1:1,000 Western blotting~~1:100~500 Immunohistochemistry~~1:50~100|
|Buffer||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles|
|Research Area||Cell Structure|
|Restrictions||For Research Use only|
Savary, Allikmets, Denizot et al.: "Isolation and chromosomal mapping of a novel ATP-binding cassette transporter conserved in mouse and human." in: Genomics, Vol. 41, Issue 2, pp. 275-8, 1997 (PubMed).
Shimada, Okuno, Kawai et al.: "Cloning and chromosomal mapping of a novel ABC transporter gene (hABC7), a candidate for X-linked sideroblastic anemia with spinocerebellar ataxia." in: Journal of human genetics, Vol. 43, Issue 2, pp. 115-22, 1998 (PubMed).
Mao, Fu, Wu et al.: "Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, Issue 14, pp. 8175-80, 1998 (PubMed).
Csere, Lill, Kispal: "Identification of a human mitochondrial ABC transporter, the functional orthologue of yeast Atm1p." in: FEBS letters, Vol. 441, Issue 2, pp. 266-70, 1999 (PubMed).
Allikmets, Raskind, Hutchinson et al.: "Mutation of a putative mitochondrial iron transporter gene (ABC7) in X-linked sideroblastic anemia and ataxia (XLSA/A)." in: Human molecular genetics, Vol. 8, Issue 5, pp. 743-9, 1999 (PubMed).
|Reactivities||Human (15), Mouse (Murine) (4), Rat (Rattus) (4), Cat (Feline) (1), Chicken (1), Cow (Bovine) (1), Dog (Canine) (1)|
|Applications||ELISA (15), Western Blotting (WB) (11), Immunohistochemistry (IHC) (6), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (5), Immunofluorescence (IF) (1), Immunoprecipitation (IP) (1)|
|Epitopes||C-Term (6), AA 733-747 (1)|