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IL1R1 antibody (Interleukin 1 Receptor, Type I) (AA 474-503)

Details for Product anti-IL1R1 Antibody No. ABIN390328, Supplier: Login to see New
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Synonyms CD121A, D2S1473, IL-1R-alpha, IL1R, IL1RA, P80, CD121a, CD121b, IL-iR, Il1r-1
AA 474-503, C-Term
(25), (21), (15), (7), (6), (6), (6), (6), (5), (4), (4), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
(101), (67), (27), (2), (1)
(106), (32), (25), (23), (2)
Clonality (Clone)
Polyclonal ()
This IL1R1 antibody is un-conjugated
(12), (8), (6), (6), (2), (2), (1), (1), (1), (1)
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(104), (94), (37), (32), (24), (23), (16), (13), (13), (6), (5), (4), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1)
Pubmed 4 references available
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Quantity 400 μL
Shipping to United States ( )
Availability Will be delivered in 2 to 4 Business Days
Immunogen This IL1R antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 474-503 AA from the C-terminal region of human IL1R.
Clone RB06973
Isotype Ig
Specificity This IL1R antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal(E487) region of human IL1R.
Predicted Reactivity Rat (Rattus)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name IL1R (IL1R1 Antibody Abstract)
Background IL1R is a member of the interleukin 1 receptor family. An experiment with transient gene expression demonstrated that this receptor was incapable of binding to interleukin 1 alpha and interleukin 1 beta with high affinity. IL1R is a receptor for interleukin 1 family member 9 (IL1F9). Binding to the agonist leads to the activation of NF-kappa-B. The gene for this protein and four other interleukin 1 receptor family genes, including interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2), interleukin 1 receptor-like 1 (IL1RL1), and interleukin 18 receptor 1 (IL18R1), form a cytokine receptor gene cluster in a region mapped to chromosome 2q12.
Synonyms: Interleukin-1 receptor-like 2 [Precursor], IL-1Rrp2, Interleukin-1 receptor-related protein 2, IL1R-rp2, IL1RL2, IL1RRP2
Molecular Weight 65405 DA
Gene ID 8808
UniProt Q9HB29
Research Area Signaling, Chromatin, Cell Structure
Pathways NF-kappaB Signaling
Application Notes WB = 1:1000, IHC (p) = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.368 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-IL1R1 antibody (Interleukin 1 Receptor, Type I) (AA 474-503) (ABIN390328) Western blot analysis of anti-IL1R (ABIN390328) in HL60 cell line lysates (35 µg/lane...
Immunohistochemistry (IHC) image for anti-IL1R1 antibody (Interleukin 1 Receptor, Type I) (AA 474-503) (ABIN390328) Formalin-fixed and paraffin-embedded human prostata carcinoma tissue reacted with IL1...
Background publications Debets, Timans, Homey et al.: "Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 167, Issue 3, pp. 1440-6, 2001 (PubMed).

Dale, Nicklin: "Interleukin-1 receptor cluster: gene organization of IL1R2, IL1R1, IL1RL2 (IL-1Rrp2), IL1RL1 (T1/ST2), and IL18R1 (IL-1Rrp) on human chromosome 2q." in: Genomics, Vol. 57, Issue 1, pp. 177-9, 1999 (PubMed).

Torigoe, Ushio, Okura et al.: "Purification and characterization of the human interleukin-18 receptor." in: The Journal of biological chemistry, Vol. 272, Issue 41, pp. 25737-42, 1997 (PubMed).

Lovenberg, Crowe, Liu et al.: "Cloning of a cDNA encoding a novel interleukin-1 receptor related protein (IL 1R-rp2)." in: Journal of neuroimmunology, Vol. 70, Issue 2, pp. 113-22, 1996 (PubMed).

Catalog No. ABIN390328
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