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IL1R1 antibody (Interleukin 1 Receptor, Type I) (AA 474-503)

Details for Product anti-IL1R1 Antibody No. ABIN390328, Supplier: Log in to see
Antigen
  • CD121A
  • D2S1473
  • IL-1R-alpha
  • IL1R
  • IL1RA
  • P80
  • CD121a
  • CD121b
  • IL-iR
  • Il1r-1
Alternatives
anti-Human IL1R1 antibody for Enzyme Immunoassay
Epitope
AA 474-503, C-Term
21
19
15
6
6
5
5
5
4
4
3
3
2
2
2
2
1
1
1
1
1
1
1
Reactivity
Human
93
61
24
2
1
Host
Rabbit
95
32
24
18
2
Clonality (Clone)
Polyclonal ()
Conjugate
This IL1R1 antibody is un-conjugated
10
8
6
5
2
2
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
92
84
35
27
22
15
15
7
7
6
5
4
3
2
2
2
2
2
2
1
1
1
Supplier
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Immunogen This IL1R antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 474-503 AA from the C-terminal region of human IL1R.
Clone RB06973
Isotype Ig
Specificity This IL1R antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal(E487) region of human IL1R.
Predicted Reactivity Rat (Rattus)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name IL1R (IL1R1 Antibody Abstract)
Background IL1R is a member of the interleukin 1 receptor family. An experiment with transient gene expression demonstrated that this receptor was incapable of binding to interleukin 1 alpha and interleukin 1 beta with high affinity. IL1R is a receptor for interleukin 1 family member 9 (IL1F9). Binding to the agonist leads to the activation of NF-kappa-B. The gene for this protein and four other interleukin 1 receptor family genes, including interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2), interleukin 1 receptor-like 1 (IL1RL1), and interleukin 18 receptor 1 (IL18R1), form a cytokine receptor gene cluster in a region mapped to chromosome 2q12.
Synonyms: Interleukin-1 receptor-like 2 [Precursor], IL-1Rrp2, Interleukin-1 receptor-related protein 2, IL1R-rp2, IL1RL2, IL1RRP2
Molecular Weight 65405 DA
Gene ID 8808
UniProt Q9HB29
Research Area Signaling, Chromatin, Cell Structure
Pathways NF-kappaB Signaling
Application Notes WB = 1:1000, IHC (p) = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.368 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-IL1R1 antibody (Interleukin 1 Receptor, Type I) (AA 474-503) (ABIN390328) Western blot analysis of anti-IL1R (ABIN390328) in HL60 cell line lysates (35 µg/lane...
Immunohistochemistry (IHC) image for anti-IL1R1 antibody (Interleukin 1 Receptor, Type I) (AA 474-503) (ABIN390328) Formalin-fixed and paraffin-embedded human prostata carcinoma tissue reacted with IL1...
Background publications Debets, Timans, Homey et al.: "Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 167, Issue 3, pp. 1440-6, 2001 (PubMed).

Dale, Nicklin: "Interleukin-1 receptor cluster: gene organization of IL1R2, IL1R1, IL1RL2 (IL-1Rrp2), IL1RL1 (T1/ST2), and IL18R1 (IL-1Rrp) on human chromosome 2q." in: Genomics, Vol. 57, Issue 1, pp. 177-9, 1999 (PubMed).

Torigoe, Ushio, Okura et al.: "Purification and characterization of the human interleukin-18 receptor." in: The Journal of biological chemistry, Vol. 272, Issue 41, pp. 25737-42, 1997 (PubMed).

Lovenberg, Crowe, Liu et al.: "Cloning of a cDNA encoding a novel interleukin-1 receptor related protein (IL 1R-rp2)." in: Journal of neuroimmunology, Vol. 70, Issue 2, pp. 113-22, 1996 (PubMed).