IL1R1 antibody (Interleukin 1 Receptor, Type I) (AA 474-503)

Catalog No. ABIN3031431

Product Details anti-IL1R1 Antibody

Target: IL1R1

Binding Specificity: AA 474-503

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL1R1 antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA, Western Blotting (WB)

Cross-Reactivity (Details): Expected species reactivity: Rat

Purification: Antigen affinity purified

Immunogen: A portion of amino acids 474-503 from human IL-1 Receptor type 1 was used as the immunogen for this IL1R1 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the IL1R1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:10-1:50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the IL1R1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Target Details for IL1R1

Target: IL1R1

Alternative Name: IL-1 Receptor type 1 (IL1R1 Products)

Synonyms: CD121A, D2S1473, IL-1R-alpha, IL1R, IL1RA, P80, CD121a, CD121b, IL-iR, Il1r-1, interleukin 1 receptor type 1, interleukin 1 receptor, type I, IL1R1, Il1r1

Background: IL1R is a member of the interleukin 1 receptor family. An experiment with transient gene expression demonstrated that this receptor was incapable of binding to interleukin 1 alpha and interleukin 1 beta with high affinity. IL1R is a receptor for interleukin 1 family member 9 (IL1F9). Binding to the agonist leads to the activation of NF-kappa-B. The gene for this protein and four other interleukin 1 receptor family genes, including interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2), interleukin 1 receptor-like 1 (IL1RL1), and interleukin 18 receptor 1 (IL18R1), form a cytokine receptor gene cluster in a region mapped to chromosome 2q12.

UniProt: P14778

Pathways: NF-kappaB Signaling, Carbohydrate Homeostasis, Cancer Immune Checkpoints