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G Protein-Coupled Receptor 37 (GPR37) (N-Term) antibody
Alternatives Western Blotting (WB), Immunohistochemistry (IHC), ELISA
|3 references available|
|Quantity||0.1 mg (0.25 mg/ml)|
|Price||280.50 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Alternative name||Pael-R (GPR37)|
|Immunogen||This Pael-R (GPR37) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 104~134 amino acids from the N-terminal region of human Pael-R (GPR37).|
|Description||Other names: Endothelin B receptor-like protein-1, ETBR-LP-1, Parkin-associated endothelin receptor-like receptor, endothelin receptor type B-like, PAELR, G protein-coupled receptor 37, GPR37|
|Characteristics||Purified Rabbit Polyclonal Antibody (Pab)|
|Specificity||This Pael-R (GPR37) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 104~134 amino acids from the N-terminal region of human Pael-R (GPR37).|
|Molecular Weight||67114 DA|
Background: Parkinson is the second most common neurodegenerative disease after Alzheimers. About 1 percent of people over the age of 65 and 3 percent of people over the age of 75 are affected by the disease. The mutation is the most common cause of Parkinson disease identified to date. The function of Park2 is not well-known, however, it may play a role in the ubiquitin-mediated proteolytic pathway. Mutations in this gene are known to cause autosomal recessive juvenile parkinsonism. Alternative splicing of this gene produces three known products of undetermined function. Panneuronal expression of Parkin substrate Pael-R causes age-dependent selective degeneration of Drosophila dopaminergic (DA) neurons, coexpression of Parkin degrades Pael-R and suppresses its toxicity.
|Application Notes||The suggested dilution is: ELISA~~1:1,000 Western blotting~~1:100~500 Immunohistochemistry~~1:50~100|
|Buffer||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles|
|Research Area||Phospho-specific antibodies, Cell Signaling, Protein Modifications, Neurology, Cell Structure|
|Restrictions||For Research Use only|
Marazziti, Golini, Gallo et al.: "Cloning of GPR37, a gene located on chromosome 7 encoding a putative G-protein-coupled peptide receptor, from a human frontal brain EST library." in: Genomics, Vol. 45, Issue 1, pp. 68-77, 1997 (PubMed).
Imai, Soda, Inoue et al.: "An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin." in: Cell, Vol. 105, Issue 7, pp. 891-902, 2001 (PubMed).
Yang, Nishimura, Imai et al.: "Parkin suppresses dopaminergic neuron-selective neurotoxicity induced by Pael-R in Drosophila." in: Neuron, Vol. 37, Issue 6, pp. 911-24, 2003 (PubMed).