LATS, Large Tumor Suppressor, Homolog 2 (Drosophila) (LATS2) (Center) antibody
| Antigen |
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| Synonyms |
KPM, FLJ13161, AV277261, AW228608, 4932411G09Rik |
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Binding Site
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| Clonality |
Polyclonal |
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Host
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Reactivity
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Conjugate
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Alexa Fluor 350 (2), Alexa Fluor 488 (2), Alexa Fluor 555 (2), Alexa Fluor 647 (2), PE,Cy5.5 (2), Alexa Flour 488 (1), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy7 (1)
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Application
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 Alternatives Western Blotting (WB), Immunohistochemistry (IHC), ELISA
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| Catalog no. |
ABIN391034 |
| Quantity |
0.1 mg (0.25 mg/ml) |
| Price |
280.50 $ Plus shipping costs $45.00
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Bulk discount
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| Shipping to |
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| Availability |
Will be delivered in 2 to 3 Business Days |
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Alternative name
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LATS2
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Gene ID
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26524
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UniProt
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Q9P2X1
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Immunogen
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This LATS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 195~224 amino acids from the center region of human LATS2.
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Isotype
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Ig
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Description
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Other names: Serine/threonine-protein kinase LATS2, Large tumor suppressor homolog 2, Serine/threonine-protein kinase kpm, Kinase phosphorylated during mitosis protein, Warts-like kinase, KPM
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Characteristics
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Purified Rabbit Polyclonal Antibody (Pab)
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Specificity
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This LATS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 195~224 amino acids from the center region of human LATS2.
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Molecular Weight
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115321 DA
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Comments
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Background: LATS2 is a serine/threonine protein kinase belonging to the LATS tumor suppressor family. This protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression.
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Application Notes
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The suggested dilution will be: ELISA~~1:1,000 Western blotting~~1:100~500 Immunohistochemistry ~~ 1:10~50
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Concentration
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0.25 mg/ml
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Purification
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Purified
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Buffer
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Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
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Storage
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Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles
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Research Area
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Phospho-specific antibodies, Protein Modifications, Cancer, Cell Structure
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Restrictions
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For Research Use only
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Product
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Blume-Jensen, Hunter: "Oncogenic kinase signalling." in: Nature, Vol. 411, Issue 6835, pp. 355-65, 2001 (PubMed).
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Alternatives for antigen "LATS, Large Tumor Suppressor, Homolog 2 (Drosophila) (LATS2)", type "Antibodies"
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Hosts
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Rabbit (31)
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Reactivities
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Human (30), Mouse (Murine) (26), Cow (Bovine) (25), Dog (Canine) (25), Rat (Rattus) (25), Horse (Equine) (24), Chicken (20), Pig (Porcine) (5), Cat (Feline) (1)
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Applications
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Immunofluorescence (IF) (23), Western Blotting (WB) (9), ELISA (8), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (5), Immunohistochemistry (IHC) (4), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (3), Immunoprecipitation (IP) (3), Immunoelectron Microscopy (IEM) (1)
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Conjugates
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Alexa Fluor 350 (2), Alexa Fluor 488 (2), Alexa Fluor 555 (2), Alexa Fluor 647 (2), PE,Cy5.5 (2), Alexa Flour 488 (1), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy7 (1)
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Epitopes
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pSer83 (4), Center (1), Internal Region (1), N-Term (1), pThr345 (1)
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2013 BioMed Central Research Awards
