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tyrosine Kinase, Non-Receptor, 2 (TNK2) (Center) antibody

Antigen

tyrosine Kinase, Non-Receptor, 2 (TNK2)
Binding Site
Alternatives

Center
Clonality Polyclonal
Host
Alternatives

Rabbit
Reactivity
Alternatives

Human
Conjugate
Alternatives Un-conjugated
Application
Alternatives Western Blotting (WB), ELISA
2 references available
Certificates ISO 9001:2008
Catalog no. ABIN392084
Quantity 0.1 mg  (0.25 mg/ml)
Price 280.50 $   Plus shipping costs $45.00
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anti-tyrosine Kinase, Non-Receptor, 2 (TNK2) (Center) antibody

Additional Information
Application Details Publications Images Alternatives back to top

Alternative name ACK1
Gene ID 10188
UniProt Q07912
Immunogen This ACK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 390~419 amino acids from the Center region of human ACK1.
Isotype Ig
Description Other names: Tyrosine kinase non-receptor protein 2, Activated CDC42 kinase 1, ACK-1, ACK1, TNK2
Characteristics Purified Rabbit Polyclonal Antibody (Pab)
Specificity This ACK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 390~419 amino acids from the Center region of human ACK1.
Molecular Weight 114327 DA
Comments

Background: ACK1 is a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway.

Application Details
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Application Notes The suggested dilution is: ELISA ~~ 1:1,000 Western blotting~~ 1:50~100
Concentration 0.25 mg/ml
Purification Purified
Buffer Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Storage Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Structure
Restrictions For Research Use only

Publications
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Product Manser, Leung, Salihuddin et al.: "A non-receptor tyrosine kinase that inhibits the GTPase activity of p21cdc42." in: Nature, Vol. 363, Issue 6427, pp. 364-7, 1993 (PubMed).

Yokoyama, Miller: "Biochemical properties of the Cdc42-associated tyrosine kinase ACK1. Substrate specificity, authphosphorylation, and interaction with Hck." in: The Journal of biological chemistry, Vol. 278, Issue 48, pp. 47713-23, 2003 (PubMed).

Alternatives
Application Details Publications Images back to top

Alternatives for antigen "tyrosine Kinase, Non-Receptor, 2 (TNK2)", type "Antibodies"
Hosts Rabbit (59), Goat (2)
Reactivities Human (60), Mouse (Murine) (35), Rat (Rattus) (34), Cow (Bovine) (29), Dog (Canine) (29), Pig (Porcine) (28), Chicken (18)
Applications Immunofluorescence (IF) (31), Western Blotting (WB) (27), ELISA (24), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (7), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (3), Immunohistochemistry (IHC) (3), Immunoprecipitation (IP) (3), Dot Blot (Dot) (2), Flow Cytometry (FACS) (1), Immunoelectron Microscopy (IEM) (1)
Conjugates Alexa Fluor 350 (4), Alexa Fluor 488 (4), Alexa Fluor 555 (4), Alexa Fluor 647 (4), PE,Cy5.5 (4), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy7 (1)
Epitopes pTyr284 (8), C-Term (5), pTyr326 (4), pTyr860,pTyr859 (4), pTyr518 (3), N-Term (2), Tyr857, Tyr858 (2), AA 161-175 (1), AA 278-289 (1), C-Term,Lys992 (1), Center (1), Center, Tyr284 (1), Tyr80 (1), pSer455 (1), pThr450 (1), pTyr826 (1), phosphorylated (1)