PKD2 antibody (Internal Region)

Catalog No. ABIN453986

The Goat Polyclonal anti-PKD2 antibody is suitable to detect PKD2 in samples from Human, Mouse, Rat and Cow. It has been validated for WB and EIA.

Quick Overview for PKD2 antibody (Internal Region) (ABIN453986)

Target: PKD2 (Polycystic Kidney Disease 2 (Autosomal Dominant) (PKD2))

Reactivity: Human, Mouse, Rat, Cow

Host: Goat

Clonality: Polyclonal

Conjugate: This PKD2 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Product Details anti-PKD2 Antibody

Binding Specificity: Internal Region

Specificity: This antibody reacts to Polycystin 2 (PKD2).

Cross-Reactivity (Details): Species reactivity (expected):Mouse, Rat, Bovine.
Species reactivity (tested):Human.

Purification: Affinity chromatography

Immunogen: Peptide with sequence C-ERAKLKRREVLGR, from the internal region of the protein sequence

Application Details

Application Notes: Peptide ELISA: 1/2000. Western blot: 1 - 3 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Target Details for PKD2

Target: PKD2 (Polycystic Kidney Disease 2 (Autosomal Dominant) (PKD2))

Alternative Name: PKD2

Background: Mutations in the polycystin 2 gene are thought to be involved in autosomal dominant polycystic kidney disease, a condition characterised by renal cyst formation. Polycystin 2 has multiple membrane spanning domains with C and N terminal cytoplasmic domains, and has been found to be localised to the plasma membrane, ER and Golgi in various cell types and in cilia. It is thought to be involved in calcium signaling and transport and has been implicated in the development and morphology of renal tubules. It has been found to be regulated by EGF signalling. Interaction with polycystin 1 via the C terminus of both proteins is thought to be important for its function.Synonyms: Autosomal dominant polycystic kidney disease type II protein, Polycystic kidney disease 2 protein, Polycystin-2, Polycystwin, R48321

Gene ID: 5311

NCBI Accession: NP_000288

UniProt: Q13563

Pathways: cAMP Metabolic Process, Maintenance of Protein Location, Negative Regulation of Transporter Activity