IL20RA antibody

Catalog No. ABIN498494

The Rabbit Polyclonal anti-IL20RA antibody is suitable to detect IL20RA in samples from Human. It has been validated for WB and IHC (p).

Quick Overview for IL20RA antibody (ABIN498494)

Target: IL20RA (Interleukin 20 Receptor alpha (IL20RA))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL20RA antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-IL20RA Antibody

Specificity: This antibody detects endogenous levels of IL-20Ralpha protein. (region surrounding Val222)

Cross-Reactivity (Details): Species reactivity (tested):Human.

Purification: Affinity Chromatography using epitope-specific immunogen.

Application Details

Application Notes: Western Blot: 1/500 - 1/1000. Immunohistochemistry: 1/50 - 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH ~7.2, 0.05 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for IL20RA

Target: IL20RA (Interleukin 20 Receptor alpha (IL20RA))

Alternative Name: IL20RA

Background: The class II cytokine receptor family includes 12 members, 11 of which combine as various heterodimers to transduce signals across the cellular membrane for 27 cytokines. These cytokines are divided into four structurally related groups: six cytokines of the IL-10 family, 17 type I IFNs, one type II IFN and three IFN-lambda. IL-20 is a member of the IL-10 family of cytokines that has been shown to be upregulated in psoriatic skin. The receptor for IL-20 (IL-20R) exists as a dimer consisting of IL-20Ralpha and IL-20Rbeta. IL-20R also functions as a receptor for IL-19, IL-24 and IL-26. It is highly expressed in skin, brain and testis. IL-20, IL-20Ralpha and IL-20Rbeta all have higher expression levels in psoriatic lesional (LS) skin than in nonlesional (NL) skin, suggesting a role for these proteins as potential therapeutic targets. IL-20 can induce signal transducer and activator of transcription (Stat) activation through IL-20R.Synonyms: Cytokine receptor class-II member 8, Cytokine receptor family 2 member 8, IL-20R-alpha, IL-20R1, Interleukin-20 receptor alpha chain, ZCYTOR7

Molecular Weight: approx. 62 kDa

Gene ID: 53832

NCBI Accession: NP_055247

UniProt: Q9UHF4